Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics
Conclusion: D-NAC has shown promising efficacy in many animal models of neurodegeneration, and this work provides evidence that modification for mitochondrial targeting can further enhance its therapeutic efficacy, particularly in diseases where oxidative stress-induced glial cell death plays a significant role in disease progression.
Source: Theranostics - Category: Molecular Biology Authors: Anjali Sharma, Kevin Liaw, Rishi Sharma, Zhi Zhang, Sujatha Kannan, Rangaramanujam M. Kannan Tags: Research Paper Source Type: research
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