Engineered RNase P Ribozymes Effectively Inhibit the Infection of Murine Cytomegalovirus in Animals

Conclusions: Our results provide the first direct evidence that novel engineered RNase P ribozyme variants with more active catalytic activity in vitro are also more effective in inhibiting viral gene expression in animals. Moreover, our studies imply the potential of engineering novel RNase P ribozyme variants with unique mutations to improve ribozyme activity for therapeutic application.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Wei Li, Yujun Liu, Yuanyuan Wang, Ruilin Li, Phong Trang, Wei Tang, Zhu Yang, Yu Wang, Xu Sun, Xiwen Xing, Sangwei Lu, Fenyong Liu Tags: Research Paper Source Type: research