Clinical significance of PD-1/PD-Ls gene amplification and overexpression in patients with hepatocellular carcinoma

Conclusions: Amplification or higher expression of PD-L1 significantly and independently correlated with unfavorable survival in HCC patients, authenticating the PD-1/PD-L1 axis as rational immunotherapeutic targets for HCC.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Li-Jie Ma, Fei-Ling Feng, Liang-Qing Dong, Zhao Zhang, Meng Duan, Long-Zi Liu, Jie-Yi Shi, Liu-Xiao Yang, Zhi-Chao Wang, Shu Zhang, Zhen-Bin Ding, Ai-Wu Ke, Ya Cao, Xiao-Ming Zhang, Jian Zhou, Jia Fan, Xiao-Ying Wang, Qiang Gao Tags: Research Paper Source Type: research