miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/ β -Catenin Axis

Conclusions: Our results indicated that miR-200c/141 played biphasic roles in breast tumor progression via affecting the BCSC heterogeneity, suggesting targeting BCSC heterogeneity to simultaneously restrict breast cancer initiation and metastasis could be a promising therapeutic strategy for breast cancer.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Bingjie Liu, Ruikai Du, Lei Zhou, Jiahui Xu, Song Chen, Ji Chen, Xiaoli Yang, Dong-xu Liu, Zhi-ming Shao, Lixing Zhang, Zuoren Yu, Ni Xie, Jun-lin Guan, Suling Liu Tags: Research Paper Source Type: research