Delivery of miR-146a to Ly6Chigh Monocytes Inhibits Pathogenic Bone Erosion in Inflammatory Arthritis

Conclusion: Our results show that classical monocytes play a critical role in arthritis bone erosion. They demonstrate the theranostics potential of manipulating miR-146a expression in Ly6Chigh monocytes to prevent joint destruction while sparing inflammation in arthritis.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Meryem Ammari, Jessy Presumey, Clara Ponsolles, Gautier Roussignol, Christine Roubert, Virginie Escriou, Karine Toupet, Anne-Laure Mausset-Bonnefont, Ma ï lys Cren, Maxime Robin, Philippe Georgel, Ramzi Nehmar, Leonie Taams, Joachim Gr ü n, Andrea Gr ü Tags: Research Paper Source Type: research