Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy

Conclusions: We have developed the first hypoxia-triggered and NTR enzyme-responsive single molecule probe for high-contrast NIR II/PA tumor imaging and hypoxia-activated photothermal therapy. By tracing the activity of NTR, IR1048-MZ may be a promising contrast agent and theranostic formulation for other hypoxia-related diseases (such as cancer, inflammation, stroke, and cardiac ischemia).

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Xiaoqing Meng, Jiali Zhang, Zhihong Sun, Lihua Zhou, Guanjun Deng, Sanpeng Li, Wenjun Li, Ping Gong, Lintao Cai Tags: Research Paper Source Type: research