Generation of an induced pluripotent stem cell cohort suitable to investigate sporadic Alzheimer's Disease

Publication date: Available online 5 December 2018Source: Stem Cell ResearchAuthor(s): David C. Schöndorf, Myriam Elschami, Maximilian Schieck, Ebru Ercan-Herbst, Christian Weber, Yasmin Riesinger, Sara Kalman, Doris Steinemann, Dagmar E. EhrnhoeferAbstractAlzheimer's Disease (AD) is the major cause of dementia in the elderly, and cortical neurons differentiated from patient-derived induced pluripotent stem cells (iPSCs) can recapitulate disease phenotypes such as tau phosphorylation or amyloid beta (Aß) deposition. Here we describe the generation of an iPSC cohort consisting of 2 sporadic AD cases and 3 controls, derived from dermal fibroblasts. All lines were karyotypically normal, showed expression of stem cell markers and efficiently differentiated into cells of all three germ layers.
Source: Stem Cell Research - Category: Stem Cells Source Type: research