Detrimental Role of miRNA-144-3p in Intracerebral Hemorrhage Induced Secondary Brain Injury is Mediated by Formyl Peptide Receptor 2 Downregulation Both In Vivo and In Vitro.

In conclusion, miRNA-144-3p aggravated ICH-induced SBI by targeting and downregulating FPR2, thereby contributing to neurological dysfunction and neural apoptosis via PI3K/AKT pathway activation. These findings suggest that inhibiting miRNA-144-3p may offer an effective approach to attenuating brain damage incurred after ICH and a potential therapy to improve ICH-induced SBI. PMID: 30511586 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30511586?dopt=Abstract

Source: Cell Transplantation - December 4, 2018 Category: Cytology Authors: Fan W, Li X, Zhang D, Li H, Shen H, Liu Y, Chen G Tags: Cell Transplant Source Type: research