Two antiproliferative seco-4,5-abietane diterpenoids from roots of Salvia ceratophylla L.

Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Hossein Hadavand Mirzaei, Omidreza Firuzi, Jima N. Chandran, Bernd Schneider, Amir Reza JassbiAbstractTwo previously undescribed rearranged abietanes, ceratol (1) and ceratodiol (2), and three known abietane-diterpenoids, including 1-ketoaethiopinone (3), ferruginol (4) and 12-deoxysalvipisone (5), were isolated from roots of Salvia ceratophylla. The structures of the purified compounds (1–5) were characterized based on analyses of their spectroscopic data, including 1D and 2D NMR and high-resolution electrospray mass spectra. The analytical data were then compared with those reported in the literature. Cytotoxicity of the isolated compounds was examined against two human cancer cell lines, MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma), using the MTT reduction assay. Whereas compound 2 showed cytotoxicity against both cancer cells, 1 showed weak toxicity against MOLT-4 cells and no toxicity against MCF-7 cells. Compound 3 and compound 5, both of which had an α, β-unsaturated carbonyl function, showed the highest cytotoxic activities among the tested compounds.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research