Chemical constituents from the twigs and leaves of Trichilia sinensis and their biological activities

Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Dong-Hua Cao, Peng Sun, Shang-Gao Liao, Li-She Gan, Lin Yang, Jian-Neng Yao, Zong-Yi Zhang, Jin-Feng Li, Xiao-Ling Zheng, Yi-Dian Xiao, Chun-Fen Xiao, Ping Zhang, Hua-Bin Hu, You-Kai XuAbstractPhytochemical investigation on the twigs and leaves of Trichilia sinensis led to the isolation of two previously undescribed limonoids (i.e., trichiliasinenoids D and E, 1 and 2), two previously undescribed phenolic acids (3 and 4), and one previously undescribed natural phenolic acid dimer (5), together with 11 known compounds (6-16). Their structures were elucidated by extensive spectroscopic analysis (IR, UV, HRESIMS, 1D and 2D NMR) and chemical techniques. The potential anti-inflammatory activities of all the compounds were evaluated in lipopolysaccharide-stimulated RAW 264.7 cells. Among these isolates, compounds 1, 2, 6, and 11-13 expressed weak NO inhibition. The antibacterial activities of all the compounds against bacteria were also tested in vitro. Compound 16 exhibited moderate antibacterial activities against Escherichia Coli.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research