Syntheses, structures and in vitro cytostatic activity of four novel homochiral organotin(IV) phosphonates

Publication date: Available online 5 December 2018Source: Journal of Organometallic ChemistryAuthor(s): Bo-Hang An, Ru-Fen Zhang, Qian-Li Li, Xiu-Mei Du, Jing Ru, Shao-Liang Zhang, Chun-Lin MaAbstractFour novel homochiral organotin phosphonates, namely, (R)-, (S)-[(Me3Sn)2(pemp)(H2O)]n (1, 2) and (R) -, (S)-[(Ph3Sn)2(pemp)2]n (3, 4) [pempH2 = (R)- or (S)-(1-phenylethylamino) methylphosphonic acid], were synthesized and characterized by X-ray diffraction analysis, elemental analysis, FT-IR, NMR (1H, 13C, 31P and 119Sn), TGA (thermogravimetric analysis) and CD (circular dichroism spectra). The structure analysis indicates that complex 1 displays 1D left-handed helical chain and complex 2 shows right-handed helical chain. These 1D chains are further linked into a 2D supramolecular network architecture through the intermolecular O–H⋯O interactions. Complexes 3 and 4 are isostructural that showing 1D infinite zig-zag chain structure. In addition, the molecules of complexes 3 and 4 are further linked through intermolecular C–H···π interactions into a 2D supramolecular structure. Furthermore, we preliminarily estimated in vitro cytostatic activity of complexes 1–4 against the human cervix tumor cells (HeLa) and the human hepatocellular carcinoma cells (HepG-2).Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research