Chronic kidney disease in low-middle income populations: a call to action for screening and prevention

Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research

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PMID: 30994543 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Calcimimetics are widely used in patients on dialysis to treat secondary hyperparathyroidism. Our current view is that bone effects are only indirect through parathyroid hormone suppression. However, because bone cells express the calcium-sensing receptor, direct calcium-sensing receptor –mediated effects are also possible. New experimental data demonstrate direct anabolic bone actions of calcimimetics, independent of parathyroid hormone suppression. Because these effects could be clinically useful, further studies are necessary to confirm the validity of this observation.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Acid retention occurs early during the course of chronic kidney disease (CKD). Studies conducted in patients with CKD suggest that alkali supplementation may slow CKD progression. However, the diagnosis of acid retention is challenging when plasma bicarbonate concentration is still normal. In this issue, Goraya et  al. suggest that urinary citrate may predict acid retention in eubicarbonatemic patients with stages 1 and 2 CKD . Although interesting, this claim yet requires confirmation by further studies.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Glomerular filtration rate (GFR) estimating equations are widely used, but their accuracy is limited by the need for race-ethnicity factors and imprecision of the estimated GFR. In this issue, Bukabau et  al. evaluated the accuracy of GFR estimating equations and race-ethnicity factors in 2 centers in sub-Saharan Africa. The authors determined that the African American factor is not applicable and that newer equations are not more accurate than the Chronic Kidney Disease Epidemiology Collaboration equations recommended by current guidelines.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Discussions focused on the optimal means for measuring blood pressure (BP) as well as managing BP in CKD patients.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: KDIGO Executive Conclusions Source Type: research
A 67-year-old man began hemodialysis at age 44 years after undergoing a right nephrectomy. Whereas a preoperative ultrasound had revealed mild renal atrophy in the absence of cysts, the histopathologic analysis of the excised kidney was consistent with nonspecific chronic kidney disease. During the following decade, the remaining kidney became severely polycystic (Figure  1a and b), and the liver was occupied by several microcysts in the absence of hepatocellular dysfunction or cholestasis based on serum measurements.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
This cohort study was conducted between January 1, 2005, and December 31, 2009.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Carotid endarterectomy should not be recommended for asymptomatic carotid stenosis in men with cancer in the past 5 years, moderate or severe chronic obstructive pulmonary disease, congestive heart failure, or chronic kidney disease Source Type: research
Conditions:   Diabetes Mellitus, Type 2;   Renal Insufficiency, Chronic Interventions:   Drug: Metformin;   Drug: Sulfonylurea;   Drug: DPP-4 inhibitor;   Drug: SGLT2 inhibitor;   Drug: GLP1 receptor agonist Sponsors:   Weill Medical College of Cornell University;   Patient-Centered Outcomes Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
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