Cumulative Antidepressant Use and Risk of Dementia Cumulative Antidepressant Use and Risk of Dementia

What are the long-term effects of antidepressant treatment on risk of dementia and late-onset Alzheimer disease? Does the risk from those with anticholinergic properties differ from those without?Journal of the American Geriatrics Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

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Authors: Goldfarb D, Sheard S, Shaughnessy L, Atri A Abstract Disclosing the diagnosis of cognitive impairment or dementia due to Alzheimer's disease (AD) and Related Dementias (ADRD) can be one of the most challenging aspects of dementia care for clinicians. However difficult the diagnosis is to give or receive, evidence and evidence-based consensus support that disclosing a timely AD/ADRD diagnosis, accompanied by psychoeducation and care planning, is beneficial to patient-care partner dyads. Diagnosis, provided as early as possible, increases the likelihood for patients to be involved in decision-making and plan...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
This study defines a new clinically relevant concept of T-cell senescence-mediated inflammatory responses in the pathophysiology of abnormal glucose homeostasis. We also found that T-cell senescence is associated with systemic inflammation and alters hepatic glucose homeostasis. The rational modulation of T-cell senescence would be a promising avenue for the treatment or prevention of diabetes. Intron Retention via Alternative Splicing as a Signature of Aging https://www.fightaging.org/archives/2019/03/intron-retention-via-alternative-splicing-as-a-signature-of-aging/ In recent years researchers have inv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
DISCUSSION: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. PMID: 30894299 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This study aimed at evaluating brain glucose metabolism, measured by [18F]FDG-PET, in patients affected by iRBD and compared to Parkinson's Disease (PD), Lewy Body Dementia (DLB), Alzheimer's Disease (AD), and controls.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Authors: Camp CJ Abstract In far too many instances treatment of persons with dementia has reflected a fundamental denial of basic human rights. At times, these individuals are treated worse than the treatment of animals when the five basic freedoms of animals, described by Pachana in her editorial, are implemented. A number of such examples of dehumanizing (and "de-animalizing") persons with dementia are presented. A case is made for the position that this is the direct result of the "medicalization" of dementia and "Alzheimer Disease." This has led to the disenfranchisement of person...
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
I was a small piece in the search to find a cure. Now I feel as if I ’ m getting erased, and medical science doesn ’ t have any answers.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Drugs (Pharmaceuticals) Memory Dementia Clinical Trials Source Type: news
Conclusion: The integrated network pharmacology method provides precise probe to illuminate the molecular mechanisms of the main volatiles of WDG for relieving senile dementia related syndromes, which will also facilitate the application of traditional Chinese medicine as an alternative or supplementary to conventional treatments of AD, as well as follow-up studies such as upgrading the quality standard of clinically applied herbal medicine and novel drug development. PMID: 30891080 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 21 March 2019Source: Alzheimer's &DementiaAuthor(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Authors: Love MCN, Pilonieta G, Geldmacher DS Abstract Objective: We assessed the clinical utility of the Alabama Brief Cognitive Screener (ABCs), an alternative to the Mini-Mental State Examination (MMSE), for cognitive screening in a new electronic medical record. Other available nonproprietary instruments were determined to be more tuned to milder deficits than the MMSE. Methods: The ABCs was administered as part of routine clinical assessment in the University of Alabama at Birmingham memory disorders clinics from April 30, 2012, to April 30, 2015. Outpatients (N = 1,589) with clinician diagnoses (ICD-9-CM)...
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
(American Physiological Society) A new article explores the pathophysiological factors that link sleep disturbances and Alzheimer's disease. Better understanding of this connection may lead to potential diagnostics and therapeutics for Alzheimer's disease, and other neurodegenerative diseases and dementia. The article is published ahead of print in the Journal of Neurophysiology (JNP).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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