FDA Warns of Rare Stroke Risk With Multiple Sclerosis Drug

WEDNESDAY, Dec. 5, 2018 -- A new warning has been added to the multiple sclerosis drug Lemtrada (alemtuzumab) after rare reports of patients suffering strokes and tears in the lining of the arteries in the head and neck, the U.S. Food and Drug...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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AbstractPurpose of ReviewThis review focuses on updates in the management of urinary incontinence occurring in older adult populations living with conditions frequently managed by physical medicine and rehabilitation specialists.Recent FindingsUrinary incontinence is common among older adults who live with neurologic diseases, such as stroke, Parkinson ’s disease, multiple sclerosis, and traumatic brain injury, and may be cared for in outpatient and acute rehabilitation facilities. While the evidence is growing regarding treatment strategies specific to patients with neurogenic bladder, behavioral treatment approache...
Source: Current Physical Medicine and Rehabilitation Reports - Category: Rehabilitation Source Type: research
ConclusionsEQ-5D research activity in neurology has been increasing through the years in studied CEE countries. There are clinical areas with the significant social burden, such as a migraine or meningitis, that are completely lacking data, other areas, such as stroke or epilepsy, with very scarce data.
Source: The European Journal of Health Economics - Category: Health Management Source Type: research
Conclusions. This systematic review reveals that EBGs seem a relevant alternative for rehabilitation at home because the effectiveness of these interventions was at least equivalent to conventional therapy or usual care. We give recommendations for the development of new EBG therapies.
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Diffuse white matter injury (dWMI) is a major cause of morbidity in the extremely preterm born infant leading to life-long neurological impairments, including deficits in cognitive, motor, sensory, psychological and behavioral functioning. At present, no treatment options are clinically available to combat dWMI and therefore exploring novel strategies is urgently needed. In recent years, the pathophysiology underlying dWMI has slowly started to be unraveled, pointing towards the disturbed maturation of oligodendrocytes (OLs) as a key mechanism. Immature OL precursor cells in the developing brain are believed to be highly s...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Dr Christoph Diener discusses new studies in neurology investigating acute ischemic stroke, carotid stenosis, migraine, multiple sclerosis, and cognitive decline.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery Commentary Source Type: news
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an as...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 4 May 2019Source: Neuroscience LettersAuthor(s): Christopher ElittAbstractZinc in an essential dietary micronutrient that is abundant in the brain with diverse roles in development, injury and neurological diseases. With new imaging tools and chelators selectively targetingzinc, the field of zinc biology is rapidly expanding. The importance ofzinc homeostasis is now well recognized in neurodegeneration but there isemerging data that zinc may be equally important in white matterdisorders. This review provides an overview on zinc biology, includingdiscussion of clinical disorders of zinc de...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Authors: Vacher P, Charlanes A, Chesnel C, Pagès A, Malot C, Le Breton F, Amarenco G, Manceau P Abstract OBJECTIVE: The aim of this article was to describe the diagnostic and therapeutic value of transcranial stimulation in pelvic and perineal disorders. METHODS: A literature review (Medline database and Google scholar) with no time limit was performed using keywords: "transcranial direct stimulation", "transcranial magnetic stimulation", "neurogenic bladder", "urinary incontinence", "Parkinson disease", "multiple sclerosis", "stroke",...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
The M.R.I. indicated one thing. Eventually a doctor found another problem entirely.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Multiple Sclerosis Stroke Dementia Cadasil Source Type: news
Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. Introduction Atherosclerosis is a systemic vascular process that is considered a major cause of cerebrovascular and cardiovascular di...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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