Mylan expands nationwide recall for blood pressure medication

Pharmaceutical firm Mylan is expanding a nationwide recall of some blood pressure medications. The recalled products could contain trace amounts of a chemical linked to cancer. CBS News medical contributor Dr. Tara Narula explains.
Source: Health News: - Category: Consumer Health News Source Type: news

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In this study, we have generated and characterised congenic mice that contain the BALB/c SuprMam1 (susceptibility) locus on a C57BL/6 (resistant) background and discovered a subtle impairment in the vitamin D/ calcium/ parathyroid hormone (PTH) pathway. This was evident as altered gene expression in the mammary glands of key players in this pathway. Further functional analysis of the mice revealed elevated PTH levels, reduced Cyp27b1 expression in kidneys, and reduced trabecular bone volume/ tissue volume percentage. Plasma 25(OH)D and serum calcium were unchanged. This impairment was a result of genetic differences and oc...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: 1 March 2019Source: Inorganica Chimica Acta, Volume 487Author(s): Ting Zhu, Tian Yu Wu, Jing Ao Ren, Su Jian Qian, Yan Li, Wan Ting Su, Deng Feng Zou, Qiao Yun Li, Jie YangAbstractTwo new coordination compounds, [Zn(pytzipa)2(H2O)4]·2H2O (1) and [Zn2(dtzpda)(H2O)5]·3H2O (2) have been synthesized by solvothermal reactions of Zn(NO3)2·6H2O with Hpytzipa or H4dtzpda, respectively (Hpytzipa = 5-(3-pyridyl)tetrazole-2-isoproponaic acid, H4dtzpda = 3,3-di(1H-tetrazol-5-yl)pentanedioic acid). The X-ray diffraction results reveal that compound 1 is a linear chain in which pytzipa acts...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 7 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ayse Basak Engin, Atilla EnginAbstractAlthough most countries regulate the aflatoxin levels in food by legislations, high amounts of aflatoxin B1 (AFB1)-DNA adducts can still be detected in normal and tumorous tissue obtained from cancer patients. AFB1 cannot directly interact with DNA unless it is biotransformed to AFB1-8, 9-epoxide via cytochrome p450 enzymes. This metabolite spontaneously and irreversibly attaches to guanine residues to generate highly mutagenic DNA adducts. AFB1-induced mutation of ATM kinase r...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
CONCLUSION: The future success of MSNs is widened because of their valuable characteristic which easily combines with various functionalities which would display enormous potential translational possibilities. PMID: 30501606 [PubMed - as supplied by publisher]
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research
ConclusionsThere have been significant improvements in pancreatic cancer care over the last decade, as evidenced by earlier diagnosis, increased utilization of surgery, and improvement in overall survival for both resected and un-resected patients.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 8 December 2018Source: Journal of Advanced ResearchAuthor(s): Hossam T. Mohamed, Ramy Gadalla, Noura El-Husseiny, Hebatallah Hassan, Zhongyan Wang, Sherif A. Ibrahim, Mohamed El-Shinawi, David H. Sherr, Mona M. MohamedAbstractThe aim of the present study was to evaluate the expression levels of the aryl hydrocarbon receptor (AHR) and its target gene CYP1B1 and to correlate their expression with Wnt5a/b-β-catenin, the CD44+/CD24(-/low) cancer stem cell (CSC) subset and factors associated with poor prognosis in inflammatory breast cancer (IBC) and non-IBC patients. The methods of analy...
Source: Journal of Advanced Research - Category: Research Source Type: research
ConclusionThese global results show that e-learning can provide statistically relevant knowledge gains in Radiographers. This course is an important contribution to the improvement of mammography education, impacting on the development of students' and radiographers’ skills.
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsResection of diaphragm metastases by MIS appears to be feasible and safe for selected patients, with similar recurrence as other abdominal sites.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Peripherally inserted central catheter, midline, and "short" midline in palliative care: Patient-reported outcome measures to assess impact on quality of care. J Vasc Access. 2018 Dec 03;:1129729818814732 Authors: Magnani C, Calvieri A, Giannarelli D, Espino M, Casale G Abstract OBJECTIVES:: A prospective, observational study was conducted in our palliative care unit to assess the impact of peripherally inserted central catheters (PICCs), midline, and "short" midline catheters on the quality of care in cancer and non-cancer patients. The secondary objective was to assess pain and di...
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
Conclusion: Our study demonstrated that CX3543 could inhibit the progression of colon cancer by downregulating CCAT1 expression and might be a potential drug for the treatment of colon cancer. PMID: 30519593 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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