Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis.

Microbial monotherapy with Prevotella histicola for patients with multiple sclerosis. Expert Rev Neurother. 2018 Dec 04;: Authors: Mangalam A, Murray J Abstract INTRODUCTION: The gut microbiome helps to maintain a person's healthy state while perturbations in its function often leading to the development of inflammatory diseases including multiple sclerosis (MS). Consequently, gut-commensals which restore homeostasis have the potential to become novel therapeutic options for treating MS. MS patients have presented gut microbial dysbiosis with a reduction in bacteria belonging to the Prevotella genus. Notably, increased levels of Prevotella are observed when disease-modifying therapies are used. Additionally, Prevotella histicola, an anaerobic bacterium derived from the human upper GI tract, can suppress disease in mice with experimental autoimmune encephalomyelitis, apreclinical MS mode. Areas covered: In this review, the authors compare MS microbiome studies from different geographical regions to identify common gut bacteria. Literature on the potential use of P. histicola as a therapy for MS and the next steps for developing microbial monotherapies in MS is also discussed. Expert commentary: Recent findings presenting an inverse correlation between Prevotella and MS disease severity as well as ability of P. histicola to suppress disease in preclinical models suggest that P. histicola might provide an additional treatment option for MS patients. However...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research