The Atomizer and Naloxone: Life-Saving Treatment for Opioid ODs
The atomizer is a handy tool to instill life-saving medication into the nose, and you should consider stocking them if you don't already. An atomizer can be used to administer naloxone and countless other drugs as well as for moderate sedation and pain control. Pediatric and adult patients alike can benefit from intranasal fentanyl or Versed. Studies on intranasal epinephrine for anaphylaxis also look promising, but it does require a higher dose—5 mg instead of 0.3 mg. (Asian Pac J Allergy Immunol 2016;34:38; http://bit.ly/2Prpjhb.)The atomizer is easy to use and can be attached to any syringe. Each spray creates a fine mist, which can penetrate the mucus membranes. You can administer about 0.5-1 mL of fluid per pump. Keep in mind the dosage of intranasal medications is often higher than that of IM, IV, and oral doses.Dr. James Roberts demonstrates the use of a traditional atomizer.Three 1 mL syringes with standard-sized atomizers. Photo by M. Roberts.Opioid StruggleMore than 33,000 people died from opioid overdoses in 2015, including prescription pain relievers, heroin, and fentanyl. (National Institute on Drug Abuse. http://bit.ly/2PrdY0D.) Naloxone is a nonselective and competitive opioid receptor antagonist, and reverses central nervous system depression caused by opioids. It can be used intravenously, intramuscularly, intranasally, and even nebulized.Naloxone has been around for almost 50 years. It is well researched, well studied, and abundantly used. The dr...
Publication date: Available online 23 September 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Vincent Laudenbach, Aude Charollais, Sophie Radi, Marie-Hélène Stumpf, Anne Vincent, Ingrid Kaltwasser, Tiphaine Tomczyk, Jacques Benichou, Philippe Leroux, Stéphane Marret
Eric Topol and Abraham Verghese talk with emergency medicine physician Uch é Blackstock about the real changes that could bring about health equity.'I'm hopeful,'she says.Medscape
Authors: Marques E, Paluch Z, Boháč P, Slanař O, Běláček J, Hercogová J Abstract INTRODUCTION: Understanding how different comorbidities and epidemiological factors are related to psoriasis severity can help us estimating patients' clinical outcome. AIM: Establish possible prognostic factors of severe psoriasis. METHODS: Three groups of patients were included: 118 were on topical therapy, 83 used conventional systemic drugs and 112 were treated with biological agents. Based of the fact that patients on topical therapy have a lower grade of disease severity than patients treated syst...
Authors: Lam PH, Hon KL, Leung K, Leong KF, Li CK, Leung TF Abstract BACKGROUND: Atopic eczema (AE) is a common relapsing inflammatory skin disease in children which is often associated with chronicity and poor quality of life. Unlike atopic asthma, control of AE is seldom assessed in therapeutics. AIM: To investigate the utility of a Traffic Light Control (TLC) system as a measurement/assessment of self-perceived eczema control. METHODS: This is a prospectively study of all Chinese children (aged 6 to 18 years old) with eczema attending the paediatric dermatology clinic of a tertiary hospital from Jan to J...
Publication date: Available online 23 September 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Igor Łoniewski, Agata Misera, Karolina Skonieczna-Żydecka, Mariusz Kaczmarczyk, Karolina Kaźmierczak-Siedlecka, Błażej Misiak, Wojciech Marlicz, Jerzy Samochowiec
This initiative aims to support the development and testing of systems-level interventions targeting high-risk youth to reduce or prevent suicide and suicidal behavior in these populations. Populations identified with high suicide risk and high unmet service need include but are not limited to: youth in public service systems, racial/ethnic minority youth, sexual and gender minority (SGM) youth, rural youth, and youth with intersectional risk. Relevant settings include but are not limited to: education or training programs, housing programs, juvenile justice, and child welfare.
The primary objective of this Funding Opportunity Announcement (FOA) is to advance translational research to better understand risk and resilience for suicide in the context of the Research Domain Criteria (RDoC) framework and the Positive Valence Systems (PVS) domain.
This FOA seeks to encourage research addressing major gaps identified in the United States Preventive Services Task Force (USPSTF) recommendation statement concerning interventions to prevent perinatal depression.
Authors: Thien F, Davies JM, Hew M, Douglass JA, O'Hehir RE Abstract INTRODUCTION: Epidemic thunderstorm asthma (ETSA) is due to a complex interaction of environmental and individual susceptibility factors, with outbreaks reported globally over the last four decades. Australia has been particularly susceptible with nearly half of episodes reported internationally, culminating in the catastrophic Melbourne 2016 event. AREAS COVERED: This narrative review focuses on primary research articles on thunderstorm asthma published since 2017 and relevant historical studies. Reported ETSA episodes are reviewed for common...
Publication date: Available online 23 September 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Virginie Rappeneau, Lars Wilmes, Chadi Touma
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