Evaluating the Cost-Effectiveness of Hydrogel Rectal Spacer in Prostate Cancer Radiation Therapy

ConclusionsBased on the current Medicare Physician Fee Schedule, HRS is cost-effective at a willingness to pay threshold of $100,000. These results contain substantial uncertainty, suggesting more evidence is needed to refine future decision-making.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research

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Rectal spacers are used to limit dose to the anterior rectal wall in high dose external beam radiation therapy of the prostate and have been shown to reduce radiation induced toxicity. Here we report the compl...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
We report our experience in prostate fiducial markers implantation through a transperineal approach.Patients and methodsBetween September 2011 and January 2018 at our center, 101 patients underwent gold seed fiducial marker transperineal ultrasound-guided implantation for prostate IGRT. We retrospectively reviewed their features and outcome. Twenty-two (21.8%) patients had previously been subjected to a transurethral prostate resection (TURP) for obstructive urinary symptoms because of benign prostatic hypertrophy. No antibiotic prophylaxis was used.ResultsThe procedure was well tolerated. In one patient, a single episode ...
Source: La Radiologia Medica - Category: Radiology Source Type: research
CONCLUSIONSBased on the current Medicare Physician Fee Schedule, HRS is cost-effective at a willingness to pay threshold of $100,000. These results contain substantial uncertainty, suggesting more evidence is needed to refine future decision making.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Authors: Chapman CH, Braunstein SE, Pouliot J, Noworolski SM, Weinberg V, Cunha A, Kurhanewicz J, Gottschalk AR, Roach MI, Hsu IC Abstract Purpose: Radiation dose escalation for prostate cancer improves biochemical control but is limited by toxicity. Magnetic resonance spectroscopic imaging (MRSI) can define dominant intraprostatic lesions (DIL). This phase I study evaluated dose escalation to MRSI-defined DIL using high-dose-rate (HDR) brachytherapy. Material and methods: Enrollment was closed early due to low accrual. Ten patients with prostate cancer (T2a-3b, Gleason 6-9, PSA
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
SpaceOARTM hydrogel (Augmentix, Inc. Burlington, MA) is a polyethylene glycol hydrogel injected into Denonvillier ′s space prior to external beam radiation therapy (EBRT) for prostate cancer to limit rectal toxicity. Intraoperative transrectal ultrasound visualizes placement of the gel. This is confirmed with magnetic resonance imaging (MRI) prior to EBRT. SpaceOARTM relies on uniform lift of the prostate awa y from the rectum to reduce rectal toxicity. This novel descriptive study analyzes the distribution of SpaceOARTM relative to the prostate.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Prostate Cancer: Localized: Radiation Therapy Source Type: research
Prostate cancer (Partin, Yoo et al. 1993, Shen, Lao et al. 2004) is a common type of cancer among men worldwide. Clinically, external beam radiation therapy (EBRT) is one of the most efficient ways for treating prostate cancer. In EBRT (de Crevoisier, Tucker et al. 2005), Computed Tomography (CT) is of great importance as it provides Hounsfield unit (HU) values, which can be used for dose planning purpose. In the planning stage of EBRT, in order to deliver prescribed dose to the prostate volume, while spare nearby normal organs from the harmful radiation, three critical pelvic organs, i.e., prostate, bladder and rectum, ne...
Source: Medical Image Analysis - Category: Radiology Authors: Source Type: research
Abstract Radiation therapy is a treatment modality that is often used in the uro-oncological setting. The common indication for the radiation therapy in the urological sphere is prostate cancer, whether it is used primarily as a radical approach, or postoperatively as adjuvant or salvage therapy. All urological organs are sensitive to radiation injury with the urinary bladder being the most susceptible with a typical cascade including acute and late changes, arising in the dose-dependent manner. The common indication for radiation therapy in urology is prostate cancer, which collaterally affects the urin...
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
Augmenix said today it won a category 1 current procedural terminology reimbursement code from the American Medical Association for periprostatic implantation of biodegradable material, covering its flagship SpaceOAR device. The SpaceOar is designed to separate the prostate from the rectal wall during radiation treatment for prostate cancer, Augmenix said. The device is delivered through a small needle as a liquid, which then solidifies into a soft gel that expands the space between the prostate and rectum during radiotherapy. The substance then liquefies and is absorbed and cleared from the body in the patient&r...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Business/Financial News Urology Augmenix Inc. Source Type: news
In the group of 6 patients, who have initially been treated with radical surgery by Miles method because of rectal cancer followed by EBRT and who were afterwards diagnosed with locally advanced prostate cancer, the brachytherapy for prostate cancer has been performed.
Source: Physica Medica: European Journal of Medical Physics - Category: Journals (General) Authors: Source Type: research
Abstract Prostate cancer treatment with definitive radiation therapy (RT) has evolved dramatically in the past 2 decades. From the initial 2-dimensional planning using X-rays, advances in technology led to 3-dimensional conformal RT, which used computerized tomography-based planning. This has allowed delivery of higher doses of radiation to the prostate while reducing dose to the surrounding organs, resulting in improved cancer control. Today, intensity-modulated RT (IMRT) is considered standard, where radiation beams of different shapes and intensities can be delivered from a wide range of angles, thus further de...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
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