Reproductive Endocrinology of Non-Alcoholic Fatty Liver Disease.

Reproductive Endocrinology of Non-Alcoholic Fatty Liver Disease. Endocr Rev. 2018 Nov 30;: Authors: Grossmann M, Wierman ME, Angus P, Handelsman DJ Abstract The liver and the reproductive system interact in a multifaceted bidirectional fashion. Sex steroid signaling influences hepatic endobiotic and xenobiotic metabolism and contributes to the pathogenesis of functional and structural disorders of the liver. In turn, liver function impacts on the reproductive axis via modulating sex steroid metabolism and transport to tissues via sex hormone binding globulin (SHBG). The liver senses the body's metabolic status and adapts its energy homeostasis in a sex-dependent fashion, a dimorphism signaled by the sex steroid milieu and possibly related to the metabolic costs of reproduction.Sex steroids impact the pathogenesis of non-alcoholic fatty liver disease, including development of hepatic steatosis, fibrosis and carcinogenesis. Preclinical studies in male rodents demonstrate that androgens protect against hepatic steatosis and insulin resistance both via androgen receptor signaling and, following aromatisation to estradiol, estrogen receptor signaling, through regulating genes involved in hepatic lipogenesis and glucose metabolism. In female rodents in contrast to males, androgens promote hepatic steatosis and dysglycemia, while estradiol is similarly protective against liver disease.In men, hepatic steatosis is associated with modest redu...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research