Hepatic and cardiac and iron overload detected by T2* magnetic resonance (MRI) in patients with myelodisplastic syndrome: a cross-sectional study

Myelodysplastic syndrome (MDS) is a heterogeneous group of disorders characterized by clonal, dysplastic, ineffective hematopoiesis and an increased propensity to develop acute myeloid leukemia (AML) [1]. Approximately 60% to 80% of patients with MDS experience symptomatic anemia, and 40% to 50% may develop transfusion-dependent anemia. Transfusion-dependent anemia is associated with the development of iron overload and decreased survival. However, iron overload may occur before patients become transfusion-dependent, since ineffective erythropoiesis suppress hepcidin production in the liver and may lead to increased iron absorption in the gut.

Source: Leukemia Research - December 4, 2018 Category: Hematology Authors: Luiz Fernando Mantovani, Fabio Pires de Souza Santos, Guilherme Fleury Perini, Claudia Mac-Donald Bley do Nascimento, Leandro de P ádua Silva, Carolina Kassab Wroclawski, Breno Pannia Esposito, Murilo Sérgio Sardo Ribeiro, Elvira Deolinda Rodrigues Pere Tags: Research paper Source Type: research