GSE117227 Rad53- and Chk1-Dependent DNA Damage Response Pathways Cooperatively Promote Fungal Pathogenesis and Modulate Antifungal Drug Susceptibility

Contributors : Kwang-Woo Jung ; Sangyong Lim ; Yong-Sun BahnSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformans var. grubiiTo elucidate the signaling circuitry downstream of Rad53, we compared transcriptome profiles between wild type and rad53 Δ mutant strains post radiation exposure using RNAseq analysis. Of total 6,962 genes, 5,087 and 4,768 genes showed statistically different expression levels in the wild type and rad53Δ mutant strains, respectively, post radiation exposure (P-value cutoff of< 0.05; false decrease rate (FDR) cutoff of< 0.05). In the wild type strain, 392 genes exhibited ≥ 2-fold expression changes post radiation exposure

Source: GEO: Gene Expression Omnibus - December 4, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cryptococcus neoformans var. grubii Source Type: research