Galactorrhea, mastodynia and gynecomastia as the first manifestation of lung adenocarcinoma. A case report

Publication date: Available online 4 December 2018Source: Respiratory Medicine Case ReportsAuthor(s): A. Lazopoulos, D. Krimiotis, N.C. Schizas, T. Rallis, A.S. Gogakos, F. Chatzinikolaou, T. Tsiouda, P. Zarogoulidis, P. Sarafis, P. Kamparoudi, D. Paliouras, N. BarbetakisAbstractGynecomastia with mastodynia and galactorrhea as a paraneoplastic syndrome due to lung cancer with complete response after surgical excision is rare.A 62-year-old Caucasian male presented with mastodynia, galactorrhea and right breast enlargement. Chest x-ray revealed a left upper lobe tumor. The patient had high levels of serum beta-human chorionic gonadotropin (b-HCG) and prolactine. Complete staging was negative for metastases.A typical left upper lobectomy with radical mediastinal lymph node dissection was performed. Pathology report was consistent with a poorly differentiated adenocarcinoma (T2N1M0). Immunohistochemically, multinucleate cells and occasional mononucleate tumor cells showed positivity for human chorionic gonadotropin.The patient received adjuvant chemotherapy with cisplatin – navelbine. One year later physical examination showed regression of both gynecomastia and mastodynia and there was no nipple discharge, while he is free from local or distant metastatic disease and the b-HCG level is normal (1,59 mIU/ml).This case represents a very rare, first manifestation of lung cancer. Galactorrhea, mastodynia and gynecomastia were the initial symptoms, which totally resolved following t...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research