Acupuncture for Aromatase Inhibitor –Related Joint Pain Among Breast Cancer Patients—Reply

In Reply As Drs Mao and Farrar point out, based on current guidelines, clinical trials reporting pain should report the proportion of patients with a clinical response (either a 2-point change on an 11-point scale or a 30% reduction). Our study was designed to detect a 2-point difference between groups. We based this on the study by Farrar et al, although we recognize now that their study did not actually define what a clinically meaningful difference between groups is. As we stated in the discussion, several recent randomized studies of pain control interventions have reported clinically meaningful between-group mean differences ranging from 0.7 to 1.0 points. Our results fell within this range.
Source: JAMA - Category: General Medicine Source Type: research

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CONCLUSION: Women with CIPN after adjuvant taxane therapy for breast cancer experienced significant improvements in neuropathic symptoms from an 8-week acupuncture treatment regimen. Additional larger studies are needed to confirm these findings. IMPLICATIONS FOR PRACTICE: Chemotherapy-induced peripheral neuropathy (CIPN) is a toxicity that often persists for months to years after the completion of adjuvant chemotherapy for early breast cancer. In a randomized pilot trial of 40 breast cancer survivors with CIPN, an 8-week acupuncture intervention (vs. usual care) led to a statistically and clinically significant impro...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
In conclusion, since most SRs were at moderate or high quality levels, CAM could be helpful for treating specific symptoms related to breast cancer. PMID: 31257250 [PubMed - in process]
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Pain after surgery remains a major health problem, calling for optimized treatment regimens to maximize the efficacy of pharmacological interventions. In this randomized controlled trial, we tested in a routine surgical treatment setting whether postoperative pain can be reduced by a brief preoperative intervention, ie, positive verbal suggestions in combination with sham acupuncture, designed to optimize treatment expectations. We hypothesized that the expectancy intervention as add-on to patient-controlled intravenous analgesia with morphine reduces patient-reported postoperative pain and improves satisfaction with analg...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Karin Meissner1,2*, Nicola Talsky1, Elisabeth Olliges1,2, Carmen Jacob1,3,4, Oliver J. Stötzer5, Christoph Salat5, Michael Braun6 and Raluca Flondor1 1Institute of Medical Psychology, Faculty of Medicine, LMU Munich, Munich, Germany 2Division of Health Promotion, Coburg University of Applied Sciences, Coburg, Germany 3Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom 4Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom 5Haematology and Oncology, Outpatient Cancer Ca...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study was a first of its kind. It involved a head-to-head comparison of acupuncture and cognitive behavioral therapy, enrolled patients with many different types of cancer and included nearly 30% minority participants. Previous studies focused solely on breast cancer and included 90% white participants. Limitations of the previous research make it difficult to determine if the results are applicable to patients with other cancers and people of diverse backgrounds. Cognitive Behavioral Therapy and Acupuncture Are Effective Acupuncture and cognitive behavioral therapy treatments produced clinically meaningful reduction...
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CONCLUSION:: Our findings suggest that acupuncture is feasible, but low recruitment rates should be considered when considering future acupuncture research in Korean breast cancer survivors. Rigorous evaluation of this symptomatic treatment strategy is now needed in the Korean population. PMID: 30896247 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - Category: Complementary Medicine Authors: Tags: Acupunct Med Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Inspiration & Hope Mental Health and Wellness Motivation and Inspiration Personal Self-Help Stigma Depression Support Depressive Episode Personal Growth Sleep stress reduction Source Type: blogs
To the Editor Dr Hershman and colleagues conducted a randomized clinical trial (RCT) of acupuncture ’s efficacy in reducing aromatase inhibitor–related joint pain among breast cancer survivors compared with sham acupuncture and waitlist control. They concluded that “the study results rejected the null hypothesis that true acupuncture generated the same outcomes as sham acupuncture and waitli st control, although the magnitude of the effect did not achieve the prespecified difference of 2 points,” having selected a 2-point difference as clinically important. However, the difference of 2 points or 30%...
Source: JAMA - Category: General Medicine Source Type: research
Conclusions: Acupuncture improved symptoms of CIPN and QoL in Korean women suffering from peripheral neuropathy after chemotherapy using taxane for breast cancer. The effects of acupuncture lasted for at least 1 month after the treatment. PMID: 30420895 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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