Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

Leukocytes continuously circulate throughout the body. He et  al. demonstrate that trafficking patterns of major leukocyte subsets occur in a rhythmic manner dependent on the time-of-day-dependent expression of lineage- and tissue-specific factors. This influences the inflammatory response and leukemic tumor burden and translates to the migration behavior of human primary lymphocytes.

Source: Immunity - December 4, 2018 Category: Allergy & Immunology Authors: Wenyan He, Stephan Holtkamp, Sophia Martina Hergenhan, Kerstin Kraus, Alba de Juan, Jasmin Weber, Paul Bradfield, Julien Martin Pierre Grenier, Jeoffrey Pelletier, David Druzd, Chien-Sin Chen, Louise Madeleine Ince, Susanne Bierschenk, Robert Pick, Markus Tags: Resource Source Type: research