Pushing 3D Printing Forward
Researchers and students have demonstrated that inks can be used instead of thermoplastic filaments to 3D print functional biomedical devices. Michael McAlpine, Benjamin Mayhugh Associate Professor of Mechanical Engineering at the University of Minnesota, described such advances in the ESC Minneapolis keynote, â3D Printing Functional Materials &Devices.â A lot of the inks McAlpineâs group uses are nanometer-scale particle inks printed at a line-width scale of 10 microns and above for printing devices at the macro level. They have developed software as well as a high-precision robotic stage whose motion is coordinated with dispensing. Multiple inks, in a variety of viscosities, have been 3D printed on the same platform. Among the breakthroughs McAlpine described are 3D-printed patient-specific organ models, 3D-printed sensors and LEDs, and 3D-printed neural regeneration devices for peripheral and central nerve repair. Organ models have been used to aid doctors and educate patients before surgery, but those made of hard plastic or rubber-like materials have had some limitations. After a request for a prostate model that âfelt like a prostate,â McAlpineâs group set out to 3D-print patient-specific models based on MRI scans using customizable soft inks. Silicone is typically difficult to print with a typical 3D printer, he said, but for use on the teamâ...
Condition: Spinal Cord Injuries Intervention: Device: transcutaneous spinal cord stimulation Sponsors: The Neurokinex Charitable Trust; International Spinal Research Trust Not yet recruiting
This study describes a single experience of SCI prevention in patients who have had endovascular repair.
Conclusion: The use of the Seal thoracic stent graft yielded good mid-term results. Further studies are needed to examine the long-term outcomes of this device. PMID: 31624711 [PubMed]
The occurrence of mechanical impingement during certain manual wheelchair tasks, even without increased load/resistance, demonstrates the importance of kinematics inherent to a task as a determinant of impingement. Frequency of and technique used to complete daily tasks should be carefully considered to reduce impingement risk, which may help preserve shoulder health long-term.
The greatest effect of increasing maneuver speed occurred during the Setup step; as speed increased, participants reduced their minimum lateral margin of stability ipsilateral to the maneuver direction. This action allowed maneuvers to be performed more quickly without requiring a greater lateral impulse during the Pushoff step. However, this strategy reduced passive stability.
Over the last 5 years multiple stakeholders in the field of spinal cord injury (SCI) research have initiated efforts to promote publications standards and to enable sharing of experimental data. In 2016 NIH/NINDS hosted representatives from the SCI communi...
ConclusionBrazilein inhibits PSD-95 activation in the corresponding segment of sciatic nerve spinal cord in BALB/c mice after sciatic nerve injury, thereby inhibiting the excessive expression of free radicals and promoting myelin regeneration.
ConclusionThese data indicate a strong association between temporal changes of the Se and Cu status and the clinical outcome after TSCI. The dynamics observed may reflect an ongoing redistribution of the trace elements in favor of a better anti-inflammatory response and a more successful neurological regeneration.
This study provides evidence that Ang-1 plays a neuroprotective role by inhibiting of autophagy expression in SCIR injury. Overall, findings could be useful for the treatment of SCIR injury. PMID: 31630316 [PubMed - as supplied by publisher]
Objective The aims of the study were to evaluate the influence of level of spinal cord injury (SCI) on caloric intake relative to total daily energy expenditure (TDEE) and body composition, and to develop a SCI–specific correction factor for the TDEE estimation. Design Individuals with paraplegia (PARA, n = 28) and tetraplegia (TETRA, n = 13) were analyzed. Daily caloric intake, basal metabolic rate, and TDEE were obtained using dietary recall, indirect calorimetry, and prediction equations, respectively. Caloric intake and TDEE were adjusted to bodyweight. Body composition was assessed using dual-energy x-ray a...
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