Vascular and metabolic profiles in offspring born to pregnant mice with metabolic syndrome treated with inositols

Inositols (INOs) supplementation during pregnancy, specifically the combination of myo-inositol (MI) and D-chiro-inositol (DCI), has been reported to improve vascular parameters in women with gestational diabetes mellitus. We demonstrated previously that offspring born to pregnant mice lacking endothelial nitric oxide synthase (eNOS+/-) gene have hypertension (HTN) as adults and when fed high fat diet (HFD) develop a metabolic syndrome (MS) phenotype.

Source: American Journal of Obstetrics and Gynecology - December 3, 2018 Category: OBGYN Authors: Monica Longo, Mesk Alrais, Esther H. Tamayo, Francesca Ferrari, Fabio Facchinetti, Jerrie S. Refuerzo, Sean C. Blackwell, Baha M. Sibai Source Type: research