Why the risks and benefits of statins are so complex

Statin side effects can vary depending on your age, sex and type of statin, when the cholesterol-lowering drugs are used to prevent cardiovascular disease, a new study suggests. Atorvastatin and rosuvastatin provided benefits at a lower 10-year risk.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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ConclusionsHigh statin users with hypercholesterolemia were associated with lower risk of overall colorectal cancer, especially proximal colon cancer in men and rectal cancer in both sexes.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionThe CRSC and Steno tools evaluated and stratified the CVR of the same population with T1D, with there being divergence of the results. It was found that the CRSC tool classified the majority of the sample as high risk. Due to this result, the eligibility to use statins, which is one of the applications of these tools, showed great differences, with the Steno tool presenting less aggressive provisions regarding the prescription of statins in patients with type 1 DM.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Authors: Andrade C Abstract Inflammatory mechanisms have been implicated in many psychiatric disorders, including depression, and anti-inflammatory agents have been suggested as potential treatments. In this context, a systematic review and meta-analysis of nonsteroidal anti-inflammatory drugs, cytokine inhibitors, glucocorticoids, statins, minocycline, and pioglitazone, all of which are considered to have anti-inflammatory properties, examined the antidepressant benefits of these agents in 36 randomized controlled trials conducted in patients with major depressive disorder (MDD) and patients with medical diseases ...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
ConclusionDNLA may improve the hepatic abnormal lipid profile of HFD-fed mice via two pathways: (1) enhancing the taurine-conjugated bile acids which are highly hydrophilic and contribute to the excretion of cholesterol; (2) decreasing the CA/CDCA ratio which is positively related to cholesterol absorption.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, our findings suggest that GGPPS provides protection against pulmonary fibrosis and the restoration of protein geranylgeranylation may benefit statin-induced lung injury. PMID: 31120854 [PubMed - as supplied by publisher]
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Taking statins before or after cancer diagnosis cuts all - cause and cancer - related deaths
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Gastroenterology, Internal Medicine, Oncology, Pharmacy, Journal, Source Type: news
Conclusion: Although preliminary, the results of the present study showed that topical atorvastatin has a comparable effect to topical betamethasone and can be considered as an alternative therapeutic modality in the treatment of scalp SD. However, these results need to be confirmed in future studies while taking into consideration the improvement of topical statin formulations. PMID: 31118730 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
FRIDAY, May 24, 2019 -- Use of statins before or after colorectal cancer (CRC) diagnosis is linked to a lower risk for premature death, from either cancer or other causes, according to a review published online May 8 in Cancer Medicine. Yue Li,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
ConclusionsNo evidence of an association between the use of metformin or statins and the incidence of breast cancer in women with T2D was found. Among insulin users, a slightly higher incidence of breast cancer was observed.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
As in non-infected subjects, statins and aspirin have a pivotal preventive role in reducing the cardiovascular related morbidity and mortality in HIV infected patients. The persistence of immune activation in ...
Source: AIDS Research and Therapy - Category: Infectious Diseases Authors: Tags: Methodology Source Type: research
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