Development of pityriasis amiantacea after valproic acid therapy

Julio A Diaz-Perez, Joel C Joyce, Thomas L Cibull, Thomas A VictorInternational Journal of Trichology 2018 10(5):237-239
Here, we present the case of a 16-year-old male who developed pityriasis amiantacea (PA) after the use of valproic acid. We propose that the keratinocyte proliferative activity of valproic acid mediated through the inhibition of glycogen synthase kinase-3β, and subsequent activation of the Wnt/β-catenin pathway could play a role in the development of PA. We additionally review the most relevant characteristics of this disease.

Source: International Journal of Trichology - December 3, 2018 Category: Dermatology Authors: Julio A Diaz-Perez Joel C Joyce Thomas L Cibull Thomas A Victor Source Type: research