Does She Have SCID?
Discussion Severe-combined immunodefiency (SCID) is actually a group of inherited disorders with an absence or dysfunction of T, B and NK cells that results in severe dysfunction of the immune system. SCID is a primary immunodeficiency. SCID was thought to be a rare disorder but with the advent of neonatal screening the incidence in the US general population is estimated at ~1 in 58,000 live births, but with numbers higher or lower depending on the specific population. Patients often have failure to thrive, oral candidiasis, and diarrhea as infants as well as a variety of infectious diseases. They can also have interstitial lung disease due to Pneumocystis jiroveci or graft-vs-host disease because of maternal lymphocyte engraphment. Without treatment to reconstitute the immune system, patients usually die at 90% long-term survival after transplantation when infants are
Abstract Stem cells are undifferentiated biological cells that can differentiate into all lineages under defined control condition. Stem cell neuronal differentiation can faithfully recapitulate stages of neural development and generate neuronal progenitors, mature neurons, and glial cells. Stem cell technology will largely allow for the replacement of animal studies and reduce costs, and will provide a new paradigm for in toxic genomics, bioinformatics, systems biology, and epigenetics studies. Here, we describe a nonadherent neuronal differentiation methodology developed in our laboratory, which can rapidly deri...
Abstract Over the last several decades, multiple recurrent chromosomal amplifications and deletions have been detected in a large number of cancers. These regions of amplification and deletion can encompass a few to several hundred genes. Determining which of these genes is causing the outgrowth of the cancer is difficult. Complicating the analysis is the fact that several genes within the affected chromosomal region may cooperate to promote tumorigenesis. In this protocol we describe a method of chromosomal engineering in mice that allows modeling of chromosomal duplications and deficiencies. This method faithful...
[AN UPDATE ON DIAGNOSIS AND MANAGEMENT OF DRUG ALLERGY]. Arerugi. 2018;67(10):1399-1404 Authors: Aihara M PMID: 30541975 [PubMed - in process]
[FOOD ALLERGY]. Arerugi. 2018;67(10):1368-1378 Authors: Yanagida N PMID: 30541971 [PubMed - in process]
"They've put together a sequence of advanced molecular and tissue engineering strategies to pull this off."
Carotid stents, more stem-cell retractions, AHA statement on statin safety, flu vaccine rules, medication errors, veterans care, and wasteful NIH research on golfing are discussed in this week ’ s podcast.theheart.org on Medscape
Elective abortion is legal in Mexico City but highly restricted elsewhere in Mexico —a situation that forces women from around the country to journey to the capital if they wish to safely terminate an unwanted pregnancy.
Adding metformin to diet and lifestyle advice does not improve pregnancy or birth outcomes in women who are overweight or obese, according to a clinical trial from Australia.Reuters Health Information
Publication date: Available online 13 December 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Mohammed Bashir, Zeinab Dabbous, Khaled Baagar, Fadi Elkhatib, Amin Ibrahim, Sanam-Alhouda Brich, Manar E. Abdel-Rahman, Justin C. Konje, Abdul-Badie Abou-SamraAbstractObjectivesTo study the pregnancy outcomes in women with type 2 diabetes mellitus (T2DM) and to relate these to maternal risk factors.MethodsWe conducted a retrospective study of 419 women with T2DM (index group)- who attended our diabetes in pregnancy clinic at the Hamad Women’s Hospital, Doha, between March 2015 ...
Conclusion: A MedDiet, enhanced with EVOO and nuts, was associated with a risk reduction of CMFOs in over 50% in normoglycemic pregnant women. Therefore, it might be a potentially adequate diet for pregnant women.Trial registration: Identifier ISRCTN84389045. The study was registered on September 27, 2013. Last edited on September 26, 2018Ann Nutr Metab 2019;74:69 –79
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