GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis

ConclusionsOur findings support the hypothesis that GM6 acts through developmental-stage pathways to influence neuron survival. Gene expression responses were consistent with neurotrophic effects, ECM modulation, and activation of the Notch and hedgehog neurodevelopmental pathways. This multifaceted mechanism of action is unique among existing ALS drug candidates and may be applicable to multiple neurodegenerative diseases.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research