Study of the bioaccumulation of tinzaparin in renally impaired patients when given at prophylactic doses - The STRIP study

Low-molecular-weight heparins (LMWHs) are used for the prevention of venous thromboembolism (VTE) [1]. Compared to unfractionated heparin (UFH), they offer a number of advantages, including a simplified dosing schedule, improved adherence and decreased risk for heparin-induced thrombocytopenia [2,3]. Severe chronic kidney disease (CKD) represents a high risk for VTE in hospitalized patients (1 –3). Clinicians typically prefer UFH over LMWH for thromboprophylaxis in severe CKD because of concerns with bioaccumulation and possible increased risk for bleeding [4,5].

Source: Thrombosis Research - December 2, 2018 Category: Hematology Authors: D. Projean, S. Lalonde, J. Morin, E. Nogues, A. Seguin, A. Vincent, J.P. Lafrance, V. Masson, J. Kassis, J. Fafard, M. Lordkipanidz é Tags: Letter to the Editors-in-Chief Source Type: research