Acute flaccid paralysis (AFP) surveillance: challenges and opportunities from 18 years' experience, Spain, 1998 to 2015.

This study describes AFP surveillance in Spain from 1998 to 2015. During this time, 678 AFP cases were reported to the Spanish National Surveillance Network. The mean notification rate was 0.58 AFP cases/100,000 population under 15 years old (range: 0.45/100,000-0.78/100,000). Two periods (P) are described: P1 (1998-2006) with the AFP notification rate ranging from 0.66/100,000 to 0.78/100,000, peaking in 2001 (0.84/100,000); and P2 (2007-2015) when the AFP rate ranged from 0.43/100,000 to 0.57/100,000, with the lowest rate in 2009 (0.31/100,000). No poliomyelitis cases were caused by wild PV infections, although two Sabin-like PVs and one imported vaccine-derived PV-2 were detected. Overall, 23 (3.4%) cases met the hot case definition. Most cases were clinically diagnosed with Guillain-Barré syndrome (76.9%; 504/655). The adequate stool collection rate ranged from 33.3% (7/21) to 72.5% (29/40). The annual proportion of AFP cases with non-polio enterovirus findings varied widely across the study period. AFP surveillance with laboratory testing for non-polio enteroviruses must be maintained and enhanced both to monitor polio eradication and to establish sensitive surveillance for prompt detection of other enteroviruses causing serious symptoms. PMID: 30482263 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research

Related Links:

This article updates our laboratory's systematic search for antigens using bioinformatics tools to clarify the Mtb H37Rv Rv3632 protein's topology and location. This article reports a C-terminal region consisting of peptides 39255 and 39256 (81Thr-Arg114) having high specific binding regarding two infection-related cell lines (A549 and U937); they inhibited mycobacterial entry to U937 cells in a concentration-dependent manner. Rv3632 forms part of the mycobacterial cell envelope, formed by six linear synthetic peptides. Circular dichroism enabled determining the protein's secondary structure. It was also found that peptide...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
[Nation] Kenya is on course in the immunisation of 800,000 girls against cervical cancer, Health Cabinet Secretary Sicily Kariuki has said, and allayed fears about the safety of the vaccine.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
(University of Maryland) In the first study of public health-related Facebook advertising, newly published in the journal Vaccine, researchers at the University of Maryland, the George Washington University and Johns Hopkins University show that a small group of anti-vaccine ad buyers has successfully leveraged Facebook to reach targeted audiences and that the social media platform's efforts to improve transparency have actually led to the removal of ads promoting vaccination and communicating scientific findings.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSIONS: As far as we know, this is the first case reported of a suppurative fistula after the resection of a cerebral abscess caused by M. bovis, therefore, there is no report in the literature about the treatment of this complication. PMID: 31713228 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Colin Havenar-Daughton, Diane G. Carnathan, Archana V. Boopathy, Amit A. Upadhyay, Ben Murrell, Samantha M. Reiss, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Pallavi Dhadvai, Federico Viviano, Kirti Kaushik, Jinal N. Bhiman, Bryan Briney, Dennis R. Burton, Steven E. Bosinger, William R. Schief, Darrell J. Irvine, Guido Silvestri, Shane CrottySummaryThe first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes (LNs), we ...
Source: Cell Reports - Category: Cytology Source Type: research
Volume 47, Issue 1, December 2019, Page 4182-4193 .
Source: Artificial Cells, Blood Substitutes, and Biotechnology - Category: Biotechnology Authors: Source Type: research
Publication date: Available online 13 November 2019Source: Veterinary MicrobiologyAuthor(s): Linlin Li, Yun Zhang, Jiawen Dong, Junqing Zhang, Chunhong Zhang, Minhua Sun, Yongchang CaoAbstractDuck Tembusu virus (DTMUV) is a major pathogen of duck industry in China. In the current study, we generated different constructs containing envelope (E) protein, pre-membrane-envelope (prM-E) protein, and C-terminally truncated E protein of the DTMUV. The constructed proteins could induce specific antibody responses in young ducks. When ducklings were immunized with the constructed proteins, they were 100% protected against DTMUV inf...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 12 November 2019Source: Veterinary ParasitologyAuthor(s): KE Lawrence, K. Gedye, WE PomroyAbstractThe aims of this study were to monitor the change in Theileria orientalis Ikeda type infection intensity, haematocrit, milk production and reproduction on three New Zealand spring calving dairy herds, over the 2014 to 2015 milking season.Three spring calving dairy farms, A, B and C, from high risk (endemically stable), low risk (endemically unstable), and zero risk (disease-free) tick areas respectively were followed through the 2014 to 2015 milking season. On Farms, A and B, 100 cows were ra...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Theoretical BiologyAuthor(s): Robert J. Hardwick, Carolin Vegvari, James E. Truscott, Roy M. AndersonAbstractBuilding on past research, we here develop an analytic framework for describing the dynamics of the transmission of soil-transmitted helminth (STH) parasitic infections near the transmission breakpoint and equilibria of endemic infection and disease extinction, while allowing for perturbations in the infectious reservoir of the parasite within a defined location. This perturbation provides a model for the effect of infected human movement between ...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: Available online 13 November 2019Source: PeptidesAuthor(s): Nigel Irwin, Victor A. Gault, Finbarr P.M. O’Harte, Peter R. FlattAbstractGastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes and promotion of fat deposition in tissues. As such, blockade of GIP receptor (GIPR) action has been proposed as a means to counter insulin resistance, and...
Source: Peptides - Category: Biochemistry Source Type: research
More News: Endemics | Enterovirus | Guillain-Barr Syndrome | Infectious Diseases | Laboratory Medicine | Polio | Polio Vaccine | Spain Health | Study | Vaccines