Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii

Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Jun-Wen Zhao, Zhong-Duo Yang, Shuan-Yan Zhou, Li-Jun Yang, Jian-Hui Sun, Xiao-Jun Yao, Zong-Mei Shu, Shuo LiAbstractTwo new pyranones, Wortmannine F (1) and G (2), were isolated from Talaromyces wortmannii LGT-4, which is an endophytic fungus from Tripterygium Wilfordii. Their structures were elucidated on the basis of NMR and ESI-MS spectral data, as well as chemical calculation. Additional known compounds (4–8) were also isolated. The isolates were tested for monoamine oxidase (MAO), acetylcholinesterase (AChE) and phosphoinositide 3-kinase α (PI3Kα) inhibitory activities. Compounds 1, 2 showed potent PI3Kα inhibitory activity with IC50 of 25 and 5 μM, respectively.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research