Where did I get dengue? Detecting spatial clusters of infection risk with social network data

Publication date: Available online 1 December 2018Source: Spatial and Spatio-temporal EpidemiologyAuthor(s): Roberto C.S.N.P. Souza, Renato M. Assunção, Derick M. Oliveira, Daniel B. Neill, Wagner MeiraAbstractTypical spatial disease surveillance systems associate a single address to each disease case reported, usually the residence address. Social network data offers a unique opportunity to obtain information on the spatial movements of individuals as well as their disease status as cases or controls. This provides information to identify visit locations with high risk of infection, even in regions where no one lives such as parks and entertainment zones. We develop two probability models to characterize the high-risk regions. We use a large Twitter dataset from Brazilian users to search for spatial clusters through analysis of the tweets’ locations and textual content. We apply our models to both real-world and simulated data, demonstrating the advantage of our models as compared to the usual spatial scan statistic for this type of data.
Source: Spatial and Spatio-temporal Epidemiology - Category: Epidemiology Source Type: research

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re AA Abstract Dengue is a re-emerging arbovirus infection of major epidemiological importance. The detection of dengue clusters is an important epidemiological surveillance strategy, contributing to better allocation of control measures and prioritizing areas that are subject to increased risk of transmission. Studies involving human populations with low mobility are scarce, and the current study thus aims to investigate the presence of persistent dengue clusters in the city of Rio de Janeiro, Brazil, in populations with different mobility and immunity. Epidemiological data on dengue were obtained from the Brazil...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
Publication date: Available online 18 October 2019Source: Microchemical JournalAuthor(s): Welma T.S. Vilar, Mayara F. Barbosa, Licarion Pinto, Mário César Ugulino de Araújo, Márcio José Coelho PontesABSTRACTAedes aegypti mosquitoes are vectors of diseases such as dengue, chikungunya, zika and yellow fever. With the increase in the incidence of these diseases the population has resorted to the use of repellents searching to protect themselves from mosquito attack. The Brazilian market offers a wide variety of products with different active principles in varying levels of concentration, tim...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of literature supports the evolving role of platelets as key sentinel and effector cells in infectious diseases, especially critical in bridging hemostatic, inflammatory, and immune continuums. Upon intravascular pathogen invasion, platelets can directly sense viral, parasitic, and bacterial infections through pattern recognition receptors and integrin receptors or pathogen: immunoglobulin complexes through Fc and complement receptors—although our understanding of these interactions remains incomplete. Constantly scanning for are...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionThe extensive spectrum of possible visual symptoms should prompt the clinician to suspect any visual complaint as potential dengue eye involvement. Guided studies and screening are needed to better understand the true incidence of eye involvement in dengue fever.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
This study has given a new insight for the novel drug designing after conducting experiments on the in vivo models.Graphical abstract
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Abstract Global incidence of dengue has drastically increased in the last few years. Despite the global morbidity and mortality associated with Dengue infection, mechanisms of immune control and viral pathogenesis are poorly explored. Pancytopenias along with increased oxidative stress are salient clinical findings in severe dengue patients. Previously, we demonstrated significant differences of circulating immune complexes (CICs) among severe and non severe dengue patients. Accordingly, here we sought to determine the contributory role of affinity purified antibody bound CICs in dengue severity. To characterise i...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
Conclusions: Major epigenetic alterations found on arboviruses infections were miR-146, miR-30e and the Dicer complex. However, existing studies frequently tested distinct hypotheses resulting in a heterogeneity of methodological approaches. Whilst epigenetic signatures associated with arbovirus infections have been reported, existing studies have largely focused on a small number of diseases, particularly dengue. Validation of epigenetic signatures have an untapped potential, but concerted investigations are certainly required to deliver robust candidates of clinical utility for diagnosis, staging and prognosis of specifi...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsOverall, our results show that the activity of pepR on pre-formed biofilms is controlled by its diffusion along the biofilm layers, an effect that can be counteracted by an additional administration of peptide. Our study sheds new light on the antibiofilm mechanism of action of antimicrobial peptides, particularly the importance of their diffusion properties through the biofilm matrix on their activity.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research
Publication date: Available online 17 May 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Cátia da Cruz Santos, Thiago Coimbra Pimenta, Ronaldo Luis Thomasini, Rodrigo Moreira Verly, Diego Leoni Franco, Lucas Franco FerreiraAbstractIn this work we synthesized, characterized (electrochemically, morphologically and structurally) and proposed an electropolymerization mechanism to obtain polymer films derived from 4-aminobenzoic acid (4-ABA), 4-aminobenzamide (4-ABZ), 4-hydroxybenzoic acid (4-HBA) and 4-hydroxybenzamide (4-HBZ) to be used as electrochemical transducers applied to the initial development of ...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 17 May 2019Source: Materials Science and Engineering: CAuthor(s): Mariappan Yazhiniprabha, Baskaralingam VaseeharanAbstractIn the present study, we investigated the larvicidal and bacteriostatic activity of biosynthesized selenium nanoparticles using aqueous berry extract of Murraya koenigii (Mk-Se NPs). The synthesized Mk-Se NPs were characterized using UV–visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis. XRD analysis re...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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