Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin.

Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin. Bioorg Med Chem. 2018 Nov 20;: Authors: Hwang CS, Ellis B, Zhou B, Janda KD Abstract Heroin is a highly abused opioid that has reached epidemic status within the United States. Yet, existing therapies to treat addiction are inadequate and frequently result into rates of high recidivism. Vaccination against heroin offers a promising alternative therapeutic option but requires further development to enhance the vaccine's performance. Hsp70 is a conserved protein with known immunomodulatory properties and is considered an excellent immunodominant antigen. Within an antidrug vaccine context, we envisioned Hsp70 as a potential dual carrier-adjuvant, wherein immunogenicity would be increased by co-localization of adjuvant and antigenic drug hapten. Recombinant Mycobacterium tuberculosis Hsp70 was appended with heroin haptens and the resulting immunoconjugate granted anti-heroin antibody production and blunted heroin-induced antinociception. Moreover, Hsp70 as a carrier protein surpassed our benchmark Her-KLH cocktail through antibody-mediated blockade of 6-acetylmorphine, the main mediator of heroin's psychoactivity. The work presents a new avenue for exploration in the use of hapten-Hsp70 conjugates to elicit anti-drug immune responses. PMID: 30497790 [PubMed - as supplied by publisher]
Source: Bioorganic and Medicinal Chemistry - Category: Chemistry Authors: Tags: Bioorg Med Chem Source Type: research

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Abstract More than 750,000 persons in the United States inject opioids, methamphetamine, cocaine, or ketamine, and that number is increasing because of the current opioid epidemic. Persons who inject drugs (PWID) are at higher risk of infectious and noninfectious skin, pulmonary, cardiac, neurologic, and other causes of morbidity and mortality. Nonjudgmental inquiries about current drug use can uncover information about readiness for addiction treatment and identify modifiable risk factors for complications of injection drug use. All PWID should be screened for human immunodeficiency virus infection, latent tuberc...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Publication date: Available online 14 July 2016 Source:The Lancet Author(s): Frederick L Altice, Lyuba Azbel, Jack Stone, Ellen Brooks-Pollock, Pavlo Smyrnov, Sergii Dvoriak, Faye S Taxman, Nabila El-Bassel, Natasha K Martin, Robert Booth, Heino Stöver, Kate Dolan, Peter Vickerman Despite global reductions in HIV incidence and mortality, the 15 UNAIDS-designated countries of Eastern Europe and Central Asia (EECA) that gained independence from the Soviet Union in 1991 constitute the only region where both continue to rise. HIV transmission in EECA is fuelled primarily by injection of opioids, with harsh ...
Source: The Lancet - Category: Journals (General) Source Type: research
Abstract Throughout Southeast Asia, repressive drug laws have resulted in high rates of imprisonment in people who inject drugs (PWID) and people living with HIV (PLH), greatly magnifying the harm associated with HIV, tuberculosis, and addiction. We review findings from Malaysia’s largest prison to describe the negative synergistic effects of HIV, tuberculosis, addiction, and incarceration that contribute to a ‘perfect storm’ of events challenging public and personal health and offer insights into innovative strategies to control these converging epidemics. The majority of PLH who are impris...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
We have the perfect storm for creating an environment that will continue to injure and destroy the health of our most precious gifts, our children. We live in America, which is the most highly vaccinated country on the planet. Vaccinations alone are responsible for tremendous health damage. We are also a country that consumes a highly processed, sugar-laden, vitamin-deficient diet, which adds its own set of health problems. Good nutrition is the cornerstone of a strong immune system capable of maintaining health and naturally fighting disease. The combination of vaccinations and poor diets contribute to our growing health ...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Stories Asthma autism autoimmune disorders Malnutrition official dietary recommendations vaccine schedule Weston Price Source Type: blogs
Abstract Waterpipe (hookah, narghile) tobacco smoking (WTS) is becoming prevalent worldwide and is one of the most popular forms of tobacco use among youth. WTS prevalence has increased dramatically among youth in the USA within the past decade. Misperceived as less harmful than cigarette smoking, WTS is associated with many of the same chronic health effects such as lung cancer, chronic obstructive pulmonary disease, cardiovascular disease, bronchitis, and asthma. Much of this risk is due to the fact that a single WTS session exposes users to large volumes of smoke that contain toxic chemicals such as carbon mono...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
Last week’s announcement of the Strategic Timing of AntiRetroviral Treatment (START) trial results confirms what many experts have long believed — early treatment for HIV reduces illness and death. While START further establishes the vital role of early antiretroviral therapy (ART), many questions remain on how to actually bring the life-saving benefits of treatment to individual patients. In many regards, the very question over when to start treatment is unusual in the field of infectious disease. “No one says we shouldn’t treat TB [tuberculosis] until the size of your cavity is 5 centimeters ...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Drugs and Medical Technology Equity and Disparities Featured Organization and Delivery Public Health Carlos del Rio HIV Medicine Association HIV-AIDS Strategic Timing of AntiRetroviral Treatment Source Type: blogs
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