Guideline-Based Physical Activity and Survival Among US Men With Nonmetastatic Prostate Cancer.

Guideline-Based Physical Activity and Survival Among US Men With Nonmetastatic Prostate Cancer. Am J Epidemiol. 2018 Nov 29;: Authors: Dickerman BA, Giovannucci E, Pernar CH, Mucci LA, Hernán MA Abstract The survival impact of adhering to current physical activity guidelines after prostate cancer diagnosis is unknown. We therefore emulated a target trial of guideline-based physical activity interventions and 10-year survival among US men with nonmetastatic prostate cancer. We used observational data on 2,299 men in the Health Professionals Follow-up Study diagnosed with nonmetastatic prostate cancer from 1998-2010 and free of conditions that might preclude participation at baseline (first post-diagnostic questionnaire). We estimated their survival under several guideline-based physical activity interventions starting at baseline and ending at the development of conditions limiting physical ability. We adjusted for baseline and time-varying risk factors for death using the parametric g-formula. Compared with the observed 15.4% mortality risk, the estimated 10-year risk (95% confidence interval, CI) of mortality was 13.0% (10.9, 15.4) and 11.1% (8.7, 14.1) for ≥1.25 and ≥2.5 hours/week of vigorous activity, and 13.9% (12.0, 16.0) and 12.6% (10.6, 14.7) for ≥2.5 and ≥5 hours/week of moderate activity, respectively. We estimated that these men would have experienced clinically meaningful reductions in mortality had they followed...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research