Modeling biological and economic uncertainty on cell therapy manufacturing: the choice of culture media supplementation.

CONCLUSION: Passage numbers in the expansion step are strongly associated with isolation cell yield and drive cost increases per donor of $1970 and 2802 for fetal bovine serum and human platelet lysate. Human platelet lysate decreases passage numbers and process costs in 94.5 and 97% of donors through lower facility and labor costs. Cost savings are maintained with full equipment depreciation and higher numbers of cells per dose, highlighting the number of cells per passage step as the key cost driver.
PMID: 30488770 [PubMed - as supplied by publisher]

Source: Regenerative Medicine - November 29, 2018 Category: Genetics & Stem Cells Authors: Bandeiras C, Cabral JM, Finkelstein SN, Ferreira FC Tags: Regen Med Source Type: research