Lung cancer detected on coronary artery calcium scoring computed tomography: factors delaying diagnosis and predictors of survival.

Lung cancer detected on coronary artery calcium scoring computed tomography: factors delaying diagnosis and predictors of survival. Acta Radiol. 2018 Nov 30;:284185118815297 Authors: Kim JY, Suh YJ, Nam K, Choi BW Abstract BACKGROUND: Lung cancers are occasionally detected on coronary artery calcium (CAC)-scoring computed tomography (CT). However, the cause of delayed diagnosis and prognostic factors have not been studied. PURPOSE: To investigate the causes of delayed diagnosis of lung cancer in patients who undergo CAC-scoring CT and to identify predictors of mortality. MATERIAL AND METHODS: A total of 151 patients who were diagnosed with lung cancer and had undergone CAC-scoring CT from January 2010 to December 2014 were retrospectively enrolled. The reasons for delayed diagnosis were reviewed. Follow-up data on all-cause mortality were obtained. Cox proportional hazards regression analysis was used to identify predictors of mortality. Analyses of solid and subsolid subgroups were performed. RESULTS: Among the 151 patients, 86 lesions (56.9%) were solid and 63 (41.7%) were subsolid. The main causes of delayed diagnosis were detection (48%) and interpretation (22%) errors. Age, size, unresectable stage at the time of diagnosis, and stage shift were independent prognostic factors throughout the entire and in the solid subgroup (all P 
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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Authors: Nardone V, Tini P, Pastina P, Botta C, Reginelli A, Carbone SF, Giannicola R, Calabrese G, Tebala C, Guida C, Giudice A, Barbieri V, Tassone P, Tagliaferri P, Cappabianca S, Capasso R, Luce A, Caraglia M, Mazzei MA, Pirtoli L, Correale P Abstract Immune checkpoint blockade is an emerging anticancer strategy, and Nivolumab is a human mAb to PD-1 that is used in the treatment of a number of different malignancies, including non-small cell lung cancer (NSCLC), kidney cancer, urothelial carcinoma and melanoma. Although the use of Nivolumab prolongs survival in a number of patients, this treatment is hampered b...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
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