Biological Effects of Bone Marrow Concentrate in Knee Pathologies

J Knee Surg DOI: 10.1055/s-0038-1676069With our aging population desiring to remain active, the incidence and costs associated with managing knee pain from both acute injury and symptomatic knee osteoarthritis continue to dramatically increase. Current treatment methods fall short with respect to their ability to improve the intra-articular environment and restore normal joint homeostasis. With increasing basic science and clinical evidence showing efficacy, cell-based therapies such as bone marrow concentrate (BMC) hold promise as a nonsurgical joint preserving treatment approach. BMC has inherent advantages over other treatments commonly used for various knee pathologies because it is a point-of-care orthobiologic product that uniquely and simultaneously delivers growth factors, anti-inflammatory proteins, and mesenchymal stem cells. There is increasing evidence for the use of BMC for repair of focal cartilage defects and for the treatment of generalized knee pain. However, continued high-quality studies are necessary for the clinical utility of BMC to be critically assessed with particular attention paid to appropriate patient selection, standardized aspiration, and processing and reporting of both functional and imaging-based outcomes. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Special Focus Section Source Type: research

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ConclusionHere we show that in twelve clinical cases, the cartilage was observed successfully regenerating and covering the defect region in knees after the intra-articular injection with adipose-derived mesenchymal stem cells (MSCs), and the treatment highly improves the symptoms of osteoarthritis. Basically, the adipose-derived MSCs from the patients are cultured and expanded to a specific amount with the optimized stem cell culture medium, the HELENE MEDIUM. After that, the cultured MSCs are directly injected into the injured knee joints of patients. The cartilage has gradually regenerated and been monitored by MRI phot...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionThis study has evidenced that there is a large percentage of sub-threshold population. i.e. K-L grade 1 which is considered as border-line or doubt-full as far as OA diagnosis. Awareness of OA should be initiated at community level, which is needed for prevention of OA at early age.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Tramadol is often prescribed for osteoarthritis pain based on a perception that it is a “safer opioid.” But is that true? Take our quick quiz to find out. 
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Osteoarthritis Source Type: news
Conclusion: Our results suggest that hip osteoarthritis and sacroiliac joint degeneration are related, and that with further investigation, the sacroiliac joint may become a new treatment target in hip osteoarthritis. Published on 2019-05-23 10:23:16
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research
Publication date: Available online 22 May 2019Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Andrew P. Dekker, Nirad Joshi, Marie Morgan, Marius Espag, Amol Tambe, David I. ClarkAbstractBackgroundMedium-term clinical results and survival of the Copeland resurfacing hemiarthroplasty of the shoulder (CRHA) in a large consecutive group are presented with a comparison of outcomes for underlying pathologies.MethodsA consecutive series of patients undergoing CRHA over 14 years was retrospectively analysed with no exclusions. Patients had a minimum 2-year follow-up by an independent assessor. Functional outcome was...
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
African Americans bear a disproportionate burden of osteoarthritis (OA), but they have been underrepresented in trials of behavioral interventions for pain. This trial examined a culturally tailored pain coping skills training (CST) program, compared to a wait list control group, among 248 African Americans with knee or hip OA. The pain CST program involved 11 telephone-based sessions over 3 months. Outcomes were assessed at baseline, 3 months (primary), and 9 months, and included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale (primary outcome), WOMAC total score and function subsc...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Few investigations examine patterns of opioid and nonopioid analgesic prescribing and concurrent pain intensity ratings before and after institution of safer prescribing programs such as the October 2013 Veterans Health Administration system-wide Opioid Safety Initiative (OSI) implementation. We conducted a quasi-experimental pre–post observational study of all older U.S. veterans (≥50 years old) with osteoarthritis of the knee or hip. All associated outpatient analgesic prescriptions and outpatient pain intensity ratings from January 1, 2012 to December 31, 2016, were analyzed with segmented regression of interru...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Listen to the Podcast or Read the Transcript [00:00:03] Hi I’m Dr. Alan Greene pediatrician and I’d like to talk with you tonight about The Brain Stage. [00:00:10] I remember vividly when I was a pediatric resident in training go to a Grand Rounds about a surprising topic. [00:00:18] The function of the brain and the function of the skin and one of the things that dermatologists talked about was a common procedure freezing warts. Freezing warts was then, and is still, one of the most common ways to get rid of warts. What she talked about was how wildly different the results were in different studies. People use...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Dr. Greene's Blog Uncategorized Cephalic Phase Placebo The Brain Stage Source Type: blogs
Publication date: Available online 21 May 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Siew-Li Goh, Monica SM Persson, Joanne Stocks, Yunfei Hou, Jianhao Lin, Michelle C Hall, Michael Doherty, Weiya ZhangAbstractBackground. Exercise is an effective treatment for osteoarthritis. However, the effect may vary from one patient (or study) to another.Objective. To evaluate the efficacy of exercise and its potential determinants for pain, function, performance, and quality of life (QoL) in knee and hip osteoarthritis (OA).Methods. We searched 9 electronic databases (AMED, CENTRAL, CINAHL, EMBASE, MEDLINE O...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Authors: Shi Y, Chen L, Xu Y, Zhang X, Ju X, Hu X, Ao Y, Wang J Abstract Acetabular labral tears are common in patients presenting with hip or groin pain. When the labrum is irreparable, labral reconstruction procedures are warranted. A circumferentially intact labrum is essential for joint health, whereas labral deficiency may predispose hip joints to osteoarthritis (OA). We aimed to determine whether labral reconstruction provides a benefit in terms of reduced OA development compared with labral resection. We performed labral reconstructions, labral resections, and sham operations in a porcine model. We assessed ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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