Fludarabine/melphalan 100 mg/m2 Conditioning Therapy Followed by Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Secondary Hemophagocytic Lymphohistiocytosis

Adult hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disease [1,2]. Furthermore, the diagnosis of HLH remains challenging, despite recent advances in diagnostic methods, including molecular testing [3,4]. The occurrence of HLH is associated with dysfunction of natural killer cells and cytotoxic T lymphocytes, which is caused in primary HLH by genetic mutations affecting the cytotoxic granule activity pathway or is caused in secondary HLH by malignancies, infections, autoimmune diseases, and medications [5,6].

Source: Biology of Blood and Marrow Transplantation - November 30, 2018 Category: Hematology Authors: Han-Seung Park, Jung-Hee Lee, Je-Hwan Lee, Eun-Ji Choi, Sun-Hye Ko, Miee Seol, Young-Shin Lee, Young-Ah Kang, Mijin Jeon, Kyoo-Hyung Lee Source Type: research