Cancers, Vol. 10, Pages 479: Helicobacter pylori Infection-Induced Hepatoma-Derived Growth Factor Regulates the Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells
Cancers, Vol. 10, Pages 479: Helicobacter pylori Infection-Induced Hepatoma-Derived Growth Factor Regulates the Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells
Cancers doi: 10.3390/cancers10120479
Authors:
Chung-Jung Liu
Yao-Kuang Wang
Fu-Chen Kuo
Wen-Hung Hsu
Fang-Jung Yu
Shuchen Hsieh
Ming-Hong Tai
Deng-Chyang Wu
Chao-Hung Kuo
Hepatoma-derived growth factor (HDGF) plays a critical role in tumor cell proliferation, anti-apoptosis, VEGF expression, lymph node metastasis and poor prognosis in human gastric cancer. Gastric cancer, as one of the most prevalent cancers worldwide, is the second leading cause of cancer-related mortality in the world for the prognosis of gastric cancer is generally poor, especially in patients with advanced stage. Helicobacter pylori (H. pylori) infection causes the chronic inflammation of stomach as well as the development of gastric cancer, with a three to six-fold increased risk of gastric cancer. Carcinoma-associated fibroblasts (CAFs) are myofibroblasts in tumor microenvironment, which possess various abilities to promote the progression of cancer by stimulating neoangiogenesis, proliferation, migration, invasion and therapy resistance of tumor cell. Mesenchymal stem cells (MSCs) are reported to promote tumor malignance through differentiation of MSCs toward CAFs. In the present study, we demonstrated that H. pylori infection promotes HDGF expression in human gastric cancer cells. HBMMSCs trea...
Source: Cancers - Category: Cancer & Oncology Authors: Chung-Jung Liu Yao-Kuang Wang Fu-Chen Kuo Wen-Hung Hsu Fang-Jung Yu Shuchen Hsieh Ming-Hong Tai Deng-Chyang Wu Chao-Hung Kuo Tags: Article Source Type: research
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