Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma

In conclusion,IDH1 orIDH2 mutations play a limited role in the development of ESCC. 2HG is potentially synthesized to high levels in the absence ofIDH1 andIDH2 mutations, and this may correlate with progression of ESCCs.
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research