Discovery by UCLA researchers could lead to better head and neck cancer therapies

UCLA scientists have discovered that a protein usually linked to rare neurological disorders is also associated with head and neck cancer in people who are infected with the human papilloma virus. And when that protein is combined with another cancer-suppressing protein, it helps improve the effectiveness of chemotherapy treatments, according to a new study by UCLA researchers. Head and neck cancer is the sixth-most common form of cancer worldwide, and represents 5 percent of cancers diagnosed annually in the United States. Of the more than 42,000 people diagnosed with head and neck cancer each year, 12,000 will die from the disease. Human papilloma virus is the most common sexually transmitted infection, and HPV diagnoses are at epidemic proportions. The Centers for Disease Control and Prevention estimate that nearly all sexually active men and women will get it at some point in their lives. Led by Dr. Eri Srivatsan and Dr. Marilene Wang, UCLA Jonsson Comprehensive Cancer Center members and co-authors of the study, researchers found the link between the protein gigaxonin and head and neck cancer while investigating the chemotherapy drug cisplatin. The drug is successfully able to kill cancer cells by interacting with the protein p16 which is commonly produced in HPV-positive cancers. “We studied the interaction of p16 in the nucleus of the cancer cell after treatment with cisplatin, and observed how the protein interacted with gigaxonin,” said Wang, professor-in-...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Antonella Stoppacciaro, Serena Di Vito, Patrizia Filetici
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 November 2018Source: Journal of Herbal MedicineAuthor(s): Andrew Croaker, Graham J. King, John H. Pyne, Shailendra Anoopkumar-Dukie, Lei LiuAbstractBlack salve, used as an alternative skin cancer therapy, contains both herbal and chemical constituents, including extracts of the rhizomes of Sanguinaria canadensis and zinc chloride. Black salves may be ordered online and have been associated with cases of extensive tissue necrosis and treatment failures that have resulted in patient fatalities. Despite these adverse outcomes and continued use by patients, black salve products have not be...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
Conclusion: In the most compromised lung cancer patients, VATS sublobar resection might be the best option.
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
The objective of this study was to analyze outcomes for patients with soft tissue sarcoma of the extremities using neoadjuvant ifosfamide-based chemotherapy and hypofractionated reduced dose radiotherapy, followed by limb-sparing surgery. Materials and Methods: An Institutional Review Board (IRB)-approved retrospective review of patients treated at a single institution between 1990 and 2013 was performed. In total, 116 patients were identified who received neoadjuvant ifosfamide-based chemotherapy and 28 Gy in 8 fractions of preoperative radiation (equivalent dose in 2 Gray fractions, 31.5 Gy [α/&bet...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
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Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
This article aims to address the challenges and management options in women who have a field effect of HPV-associated disease.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
This article aims to address the challenges and management options in women who have a field effect of HPV associated disease.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Funding Opportunity ID: 287592 Opportunity Number: CDC-RFA-GH15-15370201SUPP16 Opportunity Title: Program Expansion Supplement: Technical Assistance to Provide High-Quality Voluntary Medical Male Circumcision (VMMC) Services to Programs Supported by the President's Emergency Plan for AIDS Relief (PEPFAR)Opportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)A...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
Anogenital preinvasive and invasive lesions are known to have been on the increase in the industrialised world since the 1970s.1 The increase in anal squamous cell carcinomas and Kaposi's sarcomas (KS) has often been associated with the HIV epidemic, especially among men having sex with men. KS and non-Hodgkin's lymphoma are virus-related (KS-associated herpes virus and Epstein–Barr, respectively) AIDS-defining illnesses.2 Among anogenital cancers, only cervical cancer is listed as AIDS-defining illness. A large proportion of anogenital preinvasive and invasive lesions are human papillomavirus (HPV)-related, with a v...
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Letter Source Type: research
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