Rates of chronic kidney disease, deaths outpace other diseases

(Washington University in St. Louis) An abundance of high-sugar, high-salt foods in many American diets and obesity-related health problems such as diabetes are likely driving an increase in kidney disease cases, including in young adults, according to researchers at Washington University School of Medicine in St. Louis.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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A 52-year-old man with diabetes mellitus, congestive heart failure, morbid obesity (body mass index: 37), and chronic kidney disease started peritoneal dialysis using a surgically inserted catheter (midline incision). Catheter dysfunction necessitated surgical repositioning. During the operation, a cavity localized in the subcutaneous fat of the abdominal wall was discovered, with connection to the peritoneum space and the entire catheter within the cavity. The malfunctioning catheter was replaced through the same insertion site without an attempt to fix the cavity.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
Obesity is the global epidemic of the 21st century: about 1.5 billion adults worldwide are overweight, and among them, about 200 million men and 300 million women are obese [1]. In some countries, the prevalence of obesity has exceeded 50%, as in Tonga (men), and in Kuwait, Kiribati, Micronesia, Libya, Qatar, Tonga and Samoa (women) [2]. The prevalence of overweight and obesity are also increasing in children and adolescents in developed (about 25%) and in developing countries (about 13%) [2]. Obesity has been associated with many comorbidities, including type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (N...
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
This study reports glutathione deficiency, excess oxidative stress, and altered vitamin D metabolism in the kidney of mice fed a high-fat diet (HFD). The levels of GCLC and GCLM gene expression were significantly downregulated and the protein carbonylation level, a hallmark of oxidative damage, was significantly increased in the kidney of HFD-fed mice. While the levels of VD-regulatory genes 1-alpha-hydroxylase (CYP27B1), VDR, and RXRα were significantly downregulated in the kidney of mice fed a HFD, those of 24-hydroxylase (CYP24A1) were significantly elevated. In vitro, GSH deficiency per se causes excess oxidative...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research
In conclusion, both RH and RfH constitute challenges in clinical practice and should be addressed as distinct clinical entities by trained professionals who are capable to identify comorbidities and provide specific, diversified, and individualized treatment. PMID: 30525180 [PubMed - as supplied by publisher]
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
Abstract Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is a emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. A major complication when studying the relationship between obesity and renal injury is that cardiovascular and metabolic disorders that may result from obesity including hyperglycemia, hypertension, and dyslipidemia, or the cluster of these ...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Discussion Intrauterine growth retardation or fetal growth retardation is due to a pathological process that causes decelerated fetal growth velocity. Small-for-gestational age (SGA) is an infant with growth parameters below the normal range for gestational age. More commonly, SGA is defined as a birth weight
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Authors: Hornstrup BG, Gjoerup PH, Wessels J, Lauridsen TG, Pedersen EB, Bech JN Abstract Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-match...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
In today's healthcare environment patients require more complex care and therapies. Patients are exhibiting a growing prevalence of chronic conditions and multiple comorbidities, adding to the complexity of routine treatments. Health conditions such as diabetes, high cholesterol, chronic kidney disease, and obesity all impact patients' vessel health and complicate intravenous access. Fundamental medical care relies on intravenous access in the hospital setting and is the route for medication administration, diagnostic treatments, and other therapies.
Source: Journal of the Association for Vascular Access - Category: Cardiology Authors: Tags: Case Report Source Type: research
Purpose of review The leading cause of death in both chronic kidney disease (CKD) and renal transplant patients is cardiovascular events. Post-transplant diabetes mellitus (PTx-DM), which is a major cardiovascular risk factor, is a metabolic disorder that affects 5.5–60.2% of renal allograft recipients by 1-year posttransplant (PTx). PTx-DM has been associated with a negative impact on patient and graft outcomes and survival. Recent findings Individuals who develop PTx-DM are usually prone to this condition prior to and/or after developing CKD. Genetic factors, obesity, inflammation, medications and CKD all are ...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: SPECIAL COMMENTARIES Source Type: research
The objective of this study is to determine the prevalence of CKD and CKD risk factors among older men with moderate and severe hemophilia.Methods: This CKD cohort study is an extension of a U.S. national study sponsored by the American Thrombosis and Hemostasis Network (ATHN). The study, entitled ATHN 1: A Cross-Sectional Analysis of Cardiovascular Disease (CVD) in the Hemophilia Population, began enrollment in 10/2012. Inclusion criteria are men with moderate or severe congenital hemophilia A or B (FVIII or IX level ≤ 5%), age 54-73. Men with an additional bleeding disorder (besides liver dysfunction) were excluded. I...
Source: Blood - Category: Hematology Authors: Tags: 322. Disorders of Coagulation or Fibrinolysis: Poster II Source Type: research
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