Fast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy.
Fast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy. Phys Med Biol. 2018 Nov 28;63(23):235015 Authors: Ramos-Méndez J, Burigo LN, Schulte R, Chuang C, Faddegon B Abstract Details of the pattern of ionization formed by particle tracks extends knowledge of dose effects on the nanometer scale. Ionization detail (ID), frequently characterized by ionization cluster size distributions (ICSD), is obtained through time-consuming Monte Carlo (MC) track-structure simulations. In this work, TOPAS-nBio was used to generate a highly precise database of biologically significant ID quantities, sampled with randomly oriented 2.3 nm diameter cylinders, 3.4 nm (10 base pairs) long, inside a chromatin-size cylinder, irradiated by 1-1000 MeV/u ions of Z = 1-8. A macroscopic method developed to utilize the database using condensed-history MC was used to calculate distributions of the ICSD first moment [Formula: see text] and cumulative probability [Formula: see text] in a 20 × 20 × 40 cm3 water phantom irradiated with proton and carbon spread-out Bragg peak (SOBP) of 10.5 cm range, 2 cm width. Results were verified against detailed MC track-structure simulations using phase space scored at several depths. ID distributions were then obtained for intensity modulated proton and carbon radiothera...
Conclusion: Based on these results NDDS is considered to be an applicable instrument for identifying personality pathology in patients with depressive symptoms, by recognizing the specific pattern. This is thought to be important for adequate treatment planning. PMID: 31517547 [PubMed - as supplied by publisher]
The conversations -- all with college students between 18 and 21 -- give anecdotal looks into how the nicotine-addicted are dealing with what officials have called a public health crisis.
A 10-year-old girl is fighting for her life after she contracted a brain-eating amoeba after swimming in the Brazos River and Lake Whitney in Bosque County near Waco, Texas.
Don't do it. Please don't do it.
WHEN celebrated artist Alison Lapper began making plans for her wedding, her dream was for her son Parys to give her away.
[And we've reached the 50th Anniversary of Revista Argentina de Microbiología]. Rev Argent Microbiol. 2019 Jul - Sep;51(3):189-190 Authors: Di Conza JA, Predari SC PMID: 31514958 [PubMed - in process]
I am a big fan of Prue Leith, 79, pictured, and have no doubt her knowledge of souffles is unsurpassed, I'm not sure if the same can be said of her medical experience, writes EVE SIMMONS.
PMID: 31514692 [PubMed - in process]
As a child born in 2018, my little girl has a one in three chance of living to 100. In contrast, as someone born in 1917, Pamela would have been considered lucky to live past 60.
CONCLUSIONS Our results demonstrated a regulation loop among MATAL1, miR-194, and YAP1, which dynamically regulates the progression of AP, providing a new therapeutic target for treatment of this disease. PMID: 31518341 [PubMed - in process]