MCM2-7 complex: a review

Resumen: La formaci ón de nuevas células se genera a partir de células preexistentes a través de una serie ordenada de eventos denominada ciclo celular. El control de este es fundamental para la integridad del genoma, por lo que hay múltiples proteínas regulando este proceso. Actualmente, se conoce que el complej o MCM2-7 tiene un rol esencial en la replicación del ADN, específicamente involucrado en la proliferación, durante el ciclo celular. La identificación inmunohistoquimica de las proteínas de este complejo a nivel tisular, podría ser una herramienta muy útil, para usarlos como biomarcadores y a sí comprender uno de los mecanismos biológicos que se ven afectados en el cáncer. Nuestro objetivo es realizar una revisión del complejo MCM2-7, ya que estas proteínas como se ha descrito, podrían comportarse como buenos marcadores biológicos de proliferación celular, y así poder realizar un buen diagnóstico, pronóstico y futuros blancos terapéuticos de aquellas lesiones principalmente neoplásicas , principalmente las que asientan a nivel de la mucosa bucal.Abstract: New cells are formed from preexisting cells through an ordered series of events called cell cycle. As the control of this cycle is fundamental for genome integrity, multiple proteins regulate this process. We currently know that the MCM2...
Source: Odontoestomatologia - Category: Dentistry Source Type: research

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Authors: Michalek J, Brychtova S, Pink R, Dvorak Z Abstract Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. One possible explanation for ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
The treatment options for metastatic prostate cancer have increased dramatically over the past decade, including novel hormonal therapies, chemotherapies, and radiopharmaceuticals. The administration of myelosuppressive chemotherapies has generally been supervised by medical oncologists in the United States. The oversight of oral agents such as abiraterone  + prednisone (abi) and enzalutamide (enza) has been less well defined. This issue of the Gold Journal describes the increasing role of urologists in prescribing these agents.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
Publication date: 5 October 2019Source: International Journal of Pharmaceutics, Volume 569Author(s): Mohammed H. Qusa, Abu Bakar Siddique, Sami Nazzal, Khalid A. El SayedAbstractEpidemiological studies have compellingly documented the ability of the Mediterranean diet rich in extra-virgin olive oil to reduce the incidence of certain malignancies, and cardiovascular diseases, and slow the Alzheimer’s disease progression. S-(-)-Oleocanthal (OC) was identified as the most bioactive olive oil phenolic with documented anti-inflammatory, anticancer, and anti-Alzheimer’s activities. OC consumption causes irritating se...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
AbstractAccurate localization of the tumor during robot-assisted laparoscopic surgery for rectal cancer is crucial. Several techniques have been described, but each has its shortcomings. We developed a new technique of near infrared ray-guided surgery (NIRGS) to localize the tumor accurately, using intra-operative colonoscopy and da Vinci Firefly technology. After clamping the oral side of the tumor, the colonoscope was inserted. In the normal visible light mode, we could not recognize the endoscopic light; however, after changing to the Firefly mode, the endoscopic light was seen clearly. Using this simple and new techniq...
Source: Surgery Today - Category: Surgery Source Type: research
Publication date: 1 December 2019Source: Carbohydrate Polymers, Volume 225Author(s): Ecaterina Stela Dragan, Maria Valentina DinuAbstractMacromolecular drugs, such as proteins and peptides, are lately readily available and used in the treatment of diseases including diabetes and cancer, as well as in therapies such as gene therapy, wound dressing, and tissue engineering. However, the bioavailability, the extent and the rate at which these drugs reach the target tissue are highly dependent on the carrier and on the route of administration. Among the multitude of biocompatible polymers used to design vehicles for macromolecu...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
This article describes a framework that covers the significant stages of conceptual development and campaign design to promote oral cancer awareness in Germany. Solution: The challenges of the development, as well as evaluation of an oral cancer awareness campaign are shared in this article. Four key stages of the campaign are defined: (1) mass media, (2) target groups, (3) health care professionals, and (4) epidemiology. For each section, the following levels of assessment are proposed: (a) campaign development (formative assessment), (b) controlling and optimising campaign implementation (process assessment) and (c) meas...
Source: Community Dental Health - Category: Dentistry Tags: Community Dent Health Source Type: research
AbstractRecruitment in research can be challenging, particularly for racial/ethnic minorities and immigrants. There remains a dearth of research identifying the health and sociocultural needs of these populations related to recruitment. To describe our experiences and lessons learned in recruiting African immigrant (AI) women for the AfroPap study, a community-based study examining correlates of cervical cancer screening behaviors. We developed several recruitment strategies in collaboration with key informants and considered published recruitment methods proven effective in immigrant populations. We also evaluated the var...
Source: Journal of Community Health - Category: International Medicine & Public Health Source Type: research
miR‑378a‑3p inhibits cellular proliferation and migration in glioblastoma multiforme by targeting tetraspanin 17. Oncol Rep. 2019 Aug 20;: Authors: Guo XB, Zhang XC, Chen P, Ma LM, Shen ZQ Abstract Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and patients with this disease tend to have poor clinical outcome. MicroRNAs (miRs) are important regulators of a number of key pathways implicated in tumor pathogenesis. Recently, the expression of miR‑378 was shown to be dysregulated in several different types of cancer, including gastric cancer, colorectal cancer and oral ca...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Conditions:   Oral Cavity Cancer;   Mouth Neoplasm;   Precancerous Conditions Intervention:   Drug: Sintilimab Sponsor:   Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
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