Ask Well: What Are the Effects of Vitamin B12 Deficiency?

A deficiency of B12, if left untreated, can lead to irreversible neurological problems.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vitamins Vitamin B12 Anemia Digestive Tract Diet and Nutrition Mental Health and Disorders Celiac Disease Crohn's Disease Source Type: news

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Authors: Sonoda A, Wada Y, Togo K, Mizukami K, Fuyuno Y, Umeno J, Fujioka S, Fukuda K, Okamoto K, Ogawa R, Okimoto T, Murakami K Abstract Patients with chronic enteropathy associated with SLCO2A1 (CEAS) develop multiple circular, longitudinal, or eccentric ulcers in the ileum. It is sometimes difficult to distinguish CEAS from Crohn's disease. CEAS and primary hypertrophic osteoarthropathy (PHO) are together known to be caused by a mutation of SLCO2A1 gene. The case of a 65-year-old man whose characteristic appearance due to pachydermia of the forehead folds led to the diagnosis of CEAS with PHO is presented. P...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
ConclusionsThe exposure –response analysis suggested that intermittent 7-day veliparib 120 mg BID dosing in a 21-day cycle provided additional efficacy without meaningfully impacting the safety and tolerability when co-administered with carboplatin and paclitaxel in patients with BRCA-deficient breast cancer. A higher d ose of veliparib is unlikely to provide greater benefit in this combination in patients with BRCA-deficient recurrent or metastatic breast cancer.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
PMID: 31609194 [PubMed - in process]
Source: Public Health Nutrition - Category: International Medicine & Public Health Authors: Tags: Public Health Nutr Source Type: research
We report a novel pH-sensitive multi-compartmental nanoparticulate (MCP) oral delivery system that encapsulates siRNA for silencing the divalent metal transporter 1 (DMT1) gene, a primary iron transporter highly expressed in the intestine. The gelatin nanoparticles-coated with Eudragit® L100–55 are able to protect siRNA from intracellular degradation and allow for sustained release of siRNA in the cytosol. When orally-administered, Eudragit® L100–55 based MCPs containing DMT1 siRNA/gelatin NPs specifically and significantly decreased the expression of DMT1 mRNA in the duodenum, which consequently decrea...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: 15 October 2019Source: Cell Reports, Volume 29, Issue 3Author(s): Aly A. Khan, Leonid Yurkovetskiy, Kelly O’Grady, Joseph M. Pickard, Renée de Pooter, Dionysios A. Antonopoulos, Tatyana Golovkina, Alexander ChervonskySummaryEnvironmental influences (infections and diet) strongly affect a host’s microbiota. However, host genetics may influence commensal communities, as suggested by the greater similarity between the microbiomes of identical twins compared to non-identical twins. Variability of human genomes and microbiomes complicates the understanding of polymorphic mechanisms regulatin...
Source: Cell Reports - Category: Cytology Source Type: research
Neal McCluskeyIf you were expecting big steps forward on the Higher Education Act from the House Committee on Education and Labor, prepare to be disappointed. Yesterday, the Democratic majority released theCollege Affordability Act—which for some reason says “Est. 2019”—and it delivers pretty much what we’ve seen established since about 1969: A general conviction that what higher ed mainly needs is more government money…and no openly for-profit schools.The centerpieces of the bill are federal funds to encourage states to make community colleges free, increases in Pell Grants, cheaper st...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Publication date: Available online 15 October 2019Source: Meat ScienceAuthor(s): Alexandra E. Francisco, Martin Janíček, Teresa Dentinho, Paula Portugal, João Almeida, Susana P. Alves, Letícia Fialho, Eliana Jerónimo, Rui J.B. Bessa, José Santos-SilvaAbstractThirty-two crossbred Merino branco male lambs were randomly allocated to eight diets, combining two forms of alfalfa presentation (chopped or ground), with four barley grain levels (0%, 11.2%, 21.3% and 33% dry matter (DM)), balanced by low starch agro-industrial by-products (LSBP). The diets were supplemented with 6% soybean oil and...
Source: Meat Science - Category: Food Science Source Type: research
Publication date: January 2020Source: LWT, Volume 118Author(s): Carlos Luz, Luana Izzo, Alberto Ritieni, Jordi Mañes, Giuseppe MecaAbstractWhey is a by-product of the cheese industry, yet it contains proteins that have a high nutritional value and are an important source of antifungal peptides. Food deterioration caused by toxigenic fungi is one of the challenges of food safety. In this context, trypsin was used to hydrolyse goat milk whey at 37. The resultant peptides were characterised by LC–ESI–TOF-MS. Antifungal activity of the goat milk whey hydrolysate (HGW) was determined against 10 toxigenic fung...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 15 October 2019Source: Small Ruminant ResearchAuthor(s): Arpita Mohapatra, Ajay Kumar Shinde, Raghvendar SinghAbstractModern human diet and changes in lifestyle are emerging as a challenge in developing countries resulting to endless ailments. Thus, in modern spectra of human health, bioactive foods play a pivotal role. Under the umbrella of food and nutrition security, functional dairy foods have become the need of the hour. Sheep milk is one of the functionally active dairy foods and it is also considered as nutritional powerhouse. The beneficial role of sheep milk results from its fatt...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Publication date: Available online 15 October 2019Source: Small Ruminant ResearchAuthor(s): Santiago Luzardo, Guillermo de Souza, Graciela Quintans, Georgett BancheroAbstractThe aim of the study was to evaluate maternal energy restriction in ewes from day 48 to 106 of gestation on pre- and post-weaning lambs` performance, carcass and meat quality when their dams were fed ad libitum after the restriction period. Ewes bearing single or twin lambs were assigned to two dietary treatments from day 48 to day 106 of gestation: restricted (R) at 60% of their metabolizable energy (ME) requirements, or non-restricted (NR) at 100% of...
Source: Small Ruminant Research - Category: Zoology Source Type: research
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