The lost picornavirus ORF

For over 50 years the RNA genome of picornaviruses (illustrated below for poliovirus) was thought to be translated into a single, long polyprotein. All this time a very small upstream open reading frame (uORF) has gone undetected – until now. Analysis of over 3000 picornavirus genomes revealed a small ORF, beginning with an AUG codon, […]

Source: virology blog - November 30, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information echovirus membrane vesicles open reading frame picornavirus poliovirus polyprotein uORF viral viruses Source Type: blogs