Leptomeningeal Carcinomatosis: Prognosis and Symptom Management

Leptomeningeal carcinomatosis meningitis occurs in approximately 5% of cancer patients, causes various symptoms including serious headache, nausea, and altered mental status, and typically has A poor prognosis. Due to lack of standardized methods for pain management, opioids are commonly used; however, these often fail to achieve sufficient analgesia.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research

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In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors.The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)2}]. The structures of all mixes were completely portrayed by spectroscopic techniques (1H-NMR, 13C{1H} NMR , IR and elemental and further analyzed by DFT/...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
CONCLUSION: PSs represent a potential tool to treat this form of breast cancer by providing peptides that may be useful in therapy. PMID: 32065785 [PubMed - in process]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
Publication date: Available online 17 February 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Hombaiah Chandana, B. Madhu, M.R. Narayana MurthyAbstractIntroductionGlobally, cervical cancer is the 4th most common cancer and is one of the leading cancers causing death in India. Cervical cancer is one of those cancers which can be easily prevented by screening women who are aged above 30 years and by vaccinating young girls against HPV. Lack of awareness about cervical cancer makes early detection and timely screening difficult. Awareness about cervical cancer among people will help us to decide on an appropria...
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
ConclusionsOur findings support measurement invariance of the EORTC QLQ-C30 in a large sample of patients with hematological malignancies. The results showed that the number of non-invariant items was negligible, suggesting that this questionnaire is a valid and robust measurement tool in patients with hematological malignancies, also for comparisons across groups and time.
Source: Quality of Life Research - Category: Health Management Source Type: research
If you want to be a doctor, hold off on medical school until age 28 - STAT There are advantages to spending your formative years working at a first career and meeting your life partner, and then starting medical school at age 28. www.statnews.com "Every generation of physicians must be free to act for itself. Claims to a physician’s 20s have withered away. Corporate health care has deemed physicians replaceable, either by those who accept lower pay or by... STAT: Why Medical School Should Start at 28...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Publication date: Available online 17 February 2020Source: Surgery (Oxford)Author(s): Tristan E. McMillan, Timothy Gardner, Alan J. JohnstoneAbstractTourniquets have been around for many years, providing surgeons with a bloodless operative field and saving lives in the pre-hospital care of major limb trauma. However, their use does come with risk. It is therefore extremely important that we, as surgeons, fully understand the physiological influence they impose on patients, the complications associated with their use and, moreover, how to minimize the incidence of these complications. Most tourniquets are now electronically...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
AbstractBakker et al found a change in the magnetic resonance imaging (MRI) findings in 29 of 188 patients, when the examination was repeated at three months and at one year (1). The patients were all being investigated on account of back pain, with presumably varying degrees of concern about the possibility of inflammatory spondyloarthritis.Twelve (6.8%) patients were negative at the initial examination but became positive on subsequent testing. A percentage that was lower, but not dissimilar to Van Onna et al's report of 15% at two years (2).
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: LETTER TO THE EDITOR Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Hongying Wang, Weiping TianAbstractMicroRNAs (miRNAs) have been proven to be critical regulators of cancer development. To date, many of them are still in urgent need of characterisation, and role of miR-595 in hepatocellular carcinoma (HCC) remains unknown. To better understand the mechanism of miR-595 in HCC development, a series of experiments were carried out to explore the effects of miR-595 on malignant behaviour in HCC. First, we found that miR-595 was downregulated in HCC tissues and cells and tightly associated w...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 February 2020Source: Pathology - Research and PracticeAuthor(s): Bolin Wang, Zhong Lu, Yan Huang, Tao LinAbstractPurposeNumerous studies have reported the prognostic role of lncRNA-ATB high expression in solid tumours, but its prognostic effect is still uncertain. Therefore, the purpose of this meta-analysis was to further comprehensively verify the prognostic role of the lncRNA-ATB high expression in solid tumours.MethodsA literature search was performed using the electronic platforms to obtain relevant research studies published up to 31 May 2019. Confidence intervals of research end...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
AbstractPurpose of ReviewRecurrent meningitis is a rare clinical scenario that can be self-limiting or life threatening depending on the underlying etiology. This review describes the causes, risk factors, treatment, and prognosis for recurrent meningitis. As a general overview of a broad topic, the aim of this review is to provide clinicians with a comprehensive differential diagnosis to aide in the evaluation and management of a patient with recurrent meningitis.Recent FindingsNew developments related to understanding the pathophysiology of recurrent meningitis are as scarce as studies evaluating the treatment and preven...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
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