Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model
Continuous-flow ventricular assist devices (CF-VADs) produce non-physiologic flow with diminished pulsatility, which is a major risk factor for development of adverse events, including gastrointestinal (GI) bleeding and arteriovenous malformations (AVMs). Introduction of artificial pulsatility by modulating CF-VAD flow has been suggested as a potential solution. However, the levels of pulsatility and frequency of CF-VAD modulation necessary to prevent adverse events are currently unknown and need to be evaluated.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Thomas A. Haglund, Namakkal S. Rajasekaran, Benjamin Smood, Guruprasad A. Giridharan, Charles W. Hoopes, William L. Holman, David C. Mauchley, Sumanth D. Prabhu, Salpy V. Pamboukian, Jose A. Tallaj, Indranee N. Rajapreyar, James K. Kirklin, Palaniappan Se Tags: ORIGINAL PRE-CLINICAL SCIENCE Source Type: research
More News: Bleeding | Cardiology | Gastroenterology | Heart | Heart Transplant | Lung Transplant | Science | Transplant Surgery | Transplants